PMID- 24780059
OWN - NLM
STAT- MEDLINE
DCOM- 20141208
LR  - 20140815
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 166
IP  - 5
DP  - 2014 Sep
TI  - Acute promyelocytic leukaemia is characterized by stable incidence and improved 
      survival that is restricted to patients managed in leukaemia referral centres: a 
      pan-Canadian epidemiological study.
PG  - 660-6
LID - 10.1111/bjh.12931 [doi]
AB  - Timely diagnosis and care are major determinants of the outcome in acute 
      promyelocytic leukaemia (APL), a malignancy whose incidence may be increasing. 
      The Canadian Cancer Registry (CCR) and health system represent valuable settings 
      to study APL epidemiology. We analysed the CCR, which contains data on all 
      Canadians with APL. To provide clinical information lacking in the CCR, we 
      obtained data from five leukaemia referral centres during a similar time period. 
      Between 1993 and 2007, there were 399 APL in Canada. Age-standardized incidence 
      was 0.083/100,000 and was stable over time. The early death (ED) rate was 21.8% 
      (10.6% in patients <50 years old and 35.5% for those aged >50 years), with no 
      improvement over time. Five-year overall survival (OS) was 54.6% (73.3% in 
      patients <50 years; 29.1% older patients). In the referral cohort, 131 patients 
      were diagnosed between 1999 and 2010. ED was 14.6% and 2-year OS was 76.5%. 
      Within this cohort, ED and OS improved over time, although advanced patient age 
      remained an adverse determinant of OS. In Canada, APL incidence is unexpectedly 
      low and temporally stable. ED was higher than reported in clinical trials, but 
      similar to reports from other registries. In contrast, ED was lower in referral 
      centres and improved with time.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Paulson, Kristjan
AU  - Paulson K
AD  - University of Manitoba, Winnipeg, MB, Canada; CancerCare Manitoba, Winnipeg, MB, 
      Canada.
FAU - Serebrin, Anna
AU  - Serebrin A
FAU - Lambert, Pascal
AU  - Lambert P
FAU - Bergeron, Julie
AU  - Bergeron J
FAU - Everett, Janeve
AU  - Everett J
FAU - Kew, Andrea
AU  - Kew A
FAU - Jones, David
AU  - Jones D
FAU - Mahmud, Salah
AU  - Mahmud S
FAU - Meloche, Catherine
AU  - Meloche C
FAU - Sabloff, Mitchell
AU  - Sabloff M
FAU - Sharif, Ismail
AU  - Sharif I
FAU - Storring, John
AU  - Storring J
FAU - Turner, Donna
AU  - Turner D
FAU - Seftel, Matthew D
AU  - Seftel MD
LA  - eng
PT  - Journal Article
DEP - 20140430
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Canada/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Leukemia, Promyelocytic, Acute/*epidemiology/mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Registries
MH  - Survival Rate
OTO - NOTNLM
OT  - acute promyelocytic leukaemia
OT  - cancer registry
OT  - clinical research
OT  - early death
OT  - epidemiology
EDAT- 2014/05/02 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/05/01 06:00
PHST- 2013/08/04 00:00 [received]
PHST- 2014/03/25 00:00 [accepted]
PHST- 2014/05/01 06:00 [entrez]
PHST- 2014/05/02 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/bjh.12931 [doi]
PST - ppublish
SO  - Br J Haematol. 2014 Sep;166(5):660-6. doi: 10.1111/bjh.12931. Epub 2014 Apr 30.