PMID- 24780366
OWN - NLM
STAT- MEDLINE
DCOM- 20141031
LR  - 20220920
IS  - 1678-4391 (Electronic)
IS  - 1413-8670 (Print)
IS  - 1413-8670 (Linking)
VI  - 18
IP  - 4
DP  - 2014 Jul-Aug
TI  - The rapid and sustained responses of dendritic cells to influenza virus infection 
      in a non-human primate model.
PG  - 406-13
LID - S1413-8670(14)00070-1 [pii]
LID - 10.1016/j.bjid.2013.12.008 [doi]
AB  - Dendritic cells (DCs) are readily infected by influenza viruses and play a 
      crucial role in regulating host innate and adaptive immune responses to viral 
      infection. The aims of this study are to characterize the dynamic changes in the 
      numbers and maturation status of dendritic cells present in the lung and 
      lung-associated lymph nodes (LALNs) in the model of a non-human primate (NHP) 
      infected by influenza A virus (IAV). Cynomolgus macaques were infected with 
      influenza A virus (H3N2) via bronchoscopy. Flow cytometry was used to analyze the 
      DC numbers, maturation status and subsets during the time of acute infection 
      (days 1, 2, 3, 4, 7) and the resolution phase (day 30). A dramatic increase in 
      the numbers of influenza A virus-infected CD11c+CD14- myeloid dendritic cells 
      (mDCs) and CD11c-CD123+ plasmacytoid dendritic cells (pDCs) were observed from 
      day 1 to day 4 and peak up from day 7 post-infection. In lung and lung-associated 
      lymph nodes, the numbers and maturation status of myeloid dendritic cells and 
      plasmacytoid dendritic cells increased more slowly than those in the lung 
      tissues. On day 30 post-infection, influenza A virus challenge increased the 
      number of myeloid dendritic cells, but not plasmacytoid dendritic cells, compared 
      with baseline. These findings indicate that dendritic cells are susceptible to 
      influenza A virus infection, with the likely purpose of increasing mature myeloid 
      dendritic cells numbers in the lung and lung and lung-associated lymph nodes, 
      which provides important new insights into the regulation of dendritic cells in a 
      non-human primate model.
CI  - Copyright (c) 2014 Elsevier Editora Ltda. All rights reserved.
FAU - Jie, Zhijun
AU  - Jie Z
AD  - Department of Respiratory Medicine, The Fifth People's Hospital of Shanghai, 
      Fudan University, Shanghai, China.
FAU - Sun, Wei
AU  - Sun W
AD  - Department of Respiratory Medicine, The Fifth People's Hospital of Shanghai, 
      Fudan University, Shanghai, China.
FAU - Wang, Shanze
AU  - Wang S
AD  - Infectious Disease Program, Lovelace Respiratory Research Institute, Albuquerque, 
      NM, USA.
FAU - Koster, Frederick
AU  - Koster F
AD  - Infectious Disease Program, Lovelace Respiratory Research Institute, Albuquerque, 
      NM, USA.
FAU - Li, Bilan
AU  - Li B
AD  - Infectious Disease Program, Lovelace Respiratory Research Institute, Albuquerque, 
      NM, USA.
FAU - Harrod, Kevin S
AU  - Harrod KS
AD  - Infectious Disease Program, Lovelace Respiratory Research Institute, Albuquerque, 
      NM, USA. Electronic address: kevinsharrod@hotmail.com.
LA  - eng
GR  - K22 HL066994/HL/NHLBI NIH HHS/United States
GR  - HL-66994/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
DEP - 20140426
PL  - Brazil
TA  - Braz J Infect Dis
JT  - The Brazilian journal of infectious diseases : an official publication of the 
      Brazilian Society of Infectious Diseases
JID - 9812937
SB  - IM
EIN - Braz J Infect Dis. 2014 Sep-Oct;18(5):580
RIN - Braz J Infect Dis. 2015 Nov-Dec;19(6):677. PMID: 27030851
MH  - Animals
MH  - Cell Proliferation
MH  - Dendritic Cells/*virology
MH  - Disease Models, Animal
MH  - Flow Cytometry
MH  - Influenza A Virus, H3N2 Subtype/*immunology
MH  - Lung/*pathology
MH  - Lymph Nodes/pathology/*virology
MH  - Macaca fascicularis
MH  - Male
MH  - Myeloid Cells/*virology
MH  - Orthomyxoviridae Infections/pathology/*virology
MH  - Time Factors
PMC - PMC9478763
OTO - NOTNLM
OT  - Dendritic cells
OT  - Influenza A virus
OT  - Innate immune response
EDAT- 2014/05/02 06:00
MHDA- 2014/11/02 06:00
PMCR- 2014/04/26
CRDT- 2014/05/01 06:00
PHST- 2013/10/29 00:00 [received]
PHST- 2013/12/17 00:00 [revised]
PHST- 2013/12/24 00:00 [accepted]
PHST- 2014/05/01 06:00 [entrez]
PHST- 2014/05/02 06:00 [pubmed]
PHST- 2014/11/02 06:00 [medline]
PHST- 2014/04/26 00:00 [pmc-release]
AID - S1413-8670(14)00070-1 [pii]
AID - 10.1016/j.bjid.2013.12.008 [doi]
PST - ppublish
SO  - Braz J Infect Dis. 2014 Jul-Aug;18(4):406-13. doi: 10.1016/j.bjid.2013.12.008. 
      Epub 2014 Apr 26.