PMID- 24780503 OWN - NLM STAT- MEDLINE DCOM- 20150126 LR - 20180816 IS - 1873-5177 (Electronic) IS - 0091-3057 (Linking) VI - 122 DP - 2014 Jul TI - Spatial learning in the Morris water maze in mice genetically different in the predisposition to catalepsy: the effect of intraventricular treatment with brain-derived neurotrophic factor. PG - 266-72 LID - S0091-3057(14)00117-8 [pii] LID - 10.1016/j.pbb.2014.04.009 [doi] AB - Hereditary catalepsy in mice is accompanied with volume reduction of some brain structures and high vulnerability to inflammatory agents. Here an association between hereditary catalepsy and spatial learning deficit in the Morris water maze (MWM) in adult mouse males of catalepsy-resistant AKR, catalepsy-prone CBA and AKR.CBA-D13Mit76 (D13) strains was studied. Recombinant D13 strain was created by means of the transfer of the CBA-derived allele of the major gene of catalepsy to the AKR genome. D13 mice showed a low MWM performance in the acquisition test and high expression of the gene coding proinflammatory interleukin-6 (Il-6) in the hippocampus and cortex compared with mice of the parental AKR and CBA strains. An acute ivc administration of 300 ng of brain derived neurotrophic factor (BDNF) normalized the performance in the MWM, but did not decrease the high Il-6 gene expression in the brain of D13 mice. These results indicated a possible association between the hereditary catalepsy, MWM performance, BDNF and level of Il-6 mRNA in the brain, although the relation between these characteristics seems to be more complex. D13 recombinant mice with deficit of spatial learning is a promising model for study of the genetic and molecular mechanisms of learning disorders as well as for screening potential cognitive enhancers. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Kulikov, Alexander V AU - Kulikov AV AD - Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation; Novosibirsk State University, Novosibirsk 630090, Russian Federation. Electronic address: akulikov@ngs.ru. FAU - Fursenko, Daria V AU - Fursenko DV AD - Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation. FAU - Khotskin, Nikita V AU - Khotskin NV AD - Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation. FAU - Bazovkina, Daria V AU - Bazovkina DV AD - Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation. FAU - Kulikov, Victor A AU - Kulikov VA AD - Institute of Automation and Electrometry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation. FAU - Naumenko, Vladimir S AU - Naumenko VS AD - Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation. FAU - Bazhenova, Ekaterina Yu AU - Bazhenova EY AD - Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation. FAU - Popova, Nina K AU - Popova NK AD - Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140426 PL - United States TA - Pharmacol Biochem Behav JT - Pharmacology, biochemistry, and behavior JID - 0367050 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/*administration & dosage MH - Catalepsy/*drug therapy/*genetics MH - Genetic Predisposition to Disease/*genetics MH - Humans MH - Injections, Intraventricular MH - Male MH - Maze Learning/drug effects/*physiology MH - Mice MH - Mice, Inbred AKR MH - Mice, Inbred CBA MH - Spatial Learning/drug effects/physiology OTO - NOTNLM OT - BDNF OT - Brain OT - Catalepsy OT - Il-6 mRNA OT - Mice OT - Morris water maze EDAT- 2014/05/02 06:00 MHDA- 2015/01/27 06:00 CRDT- 2014/05/01 06:00 PHST- 2013/11/06 00:00 [received] PHST- 2014/04/09 00:00 [revised] PHST- 2014/04/18 00:00 [accepted] PHST- 2014/05/01 06:00 [entrez] PHST- 2014/05/02 06:00 [pubmed] PHST- 2015/01/27 06:00 [medline] AID - S0091-3057(14)00117-8 [pii] AID - 10.1016/j.pbb.2014.04.009 [doi] PST - ppublish SO - Pharmacol Biochem Behav. 2014 Jul;122:266-72. doi: 10.1016/j.pbb.2014.04.009. Epub 2014 Apr 26.