PMID- 24780604
OWN - NLM
STAT- MEDLINE
DCOM- 20150804
LR  - 20220310
IS  - 1872-7131 (Electronic)
IS  - 0387-7604 (Linking)
VI  - 37
IP  - 1
DP  - 2015 Jan
TI  - Maternal viral infection during pregnancy impairs development of fetal 
      serotonergic neurons.
PG  - 88-93
LID - S0387-7604(14)00084-9 [pii]
LID - 10.1016/j.braindev.2014.03.007 [doi]
AB  - BACKGROUND: Maternal viral infection during pregnancy induces morphological 
      abnormalities in the fetus and may cause emotional and psychological problems in 
      offspring through unknown mechanisms. We have previously shown that prenatal 
      exposure of rats to chemicals such as thalidomide causes an autistic-like 
      phenotype in offspring, indicating that prenatal events affecting serotonergic 
      development may cause developmental disorder. METHODS: We investigated whether 
      prenatal viral infection altered the expression of neurotransmitters involved in 
      the emotional or psychological status of offspring. We here took advantage of the 
      polyriboinosinic:polyribocytidylic acid (poly I:C) system, the synthetic 
      double-stranded RNA, which is often used in animal models of viral infection. 
      RESULTS: Ten mg/kg of poly I:C was intraperitoneally injected on gestational day 
      (GD) 9 and counted the numbers of serotonin-immunopositive cells on GD15 using 
      flat whole-mount preparation method, resulting 11.1% of increase in the number of 
      serotonergic neurons in poly I:C group. Furthermore, there was a significant 
      decrease in hippocampal serotonin content in offspring by postnatal day 50 
      following poly I:C administration by high-performance liquid chromatography. 
      DISCUSSION AND CONCLUSION: Since serotonin is known to link with behavior and 
      emotion after birth, these results suggest that maternal viral infection might 
      cause, in addition to morphological abnormalities, serotonin-related pathogenesis 
      such as neurodevelopmental disorders including autism spectrum disorders.
CI  - Copyright (c) 2014 The Japanese Society of Child Neurology. Published by Elsevier 
      B.V. All rights reserved.
FAU - Ohkawara, Takeshi
AU  - Ohkawara T
AD  - Department of Developmental and Regenerative Medicine, Mie University, Graduate 
      School of Medicine, Mie, Japan. Electronic address: 
      tohkawara@doc.medic.mie-u.ac.jp.
FAU - Katsuyama, Takashi
AU  - Katsuyama T
AD  - Department of Developmental and Regenerative Medicine, Mie University, Graduate 
      School of Medicine, Mie, Japan.
FAU - Ida-Eto, Michiru
AU  - Ida-Eto M
AD  - Department of Developmental and Regenerative Medicine, Mie University, Graduate 
      School of Medicine, Mie, Japan.
FAU - Narita, Naoko
AU  - Narita N
AD  - Department of Education, Bunkyo University, Saitama, Japan.
FAU - Narita, Masaaki
AU  - Narita M
AD  - Department of Developmental and Regenerative Medicine, Mie University, Graduate 
      School of Medicine, Mie, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140426
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Animals
MH  - Brain/*pathology
MH  - Chromatography, High Pressure Liquid
MH  - Disease Models, Animal
MH  - Female
MH  - Fetus
MH  - In Situ Hybridization
MH  - Poly I-C/toxicity
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*pathology
MH  - Prenatal Exposure Delayed Effects/*pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Real-Time Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Serotonergic Neurons/*pathology
MH  - Virus Diseases/*complications
OTO - NOTNLM
OT  - Autism
OT  - Maternal viral infection
OT  - Poly I:C
OT  - Serotonin
EDAT- 2014/05/02 06:00
MHDA- 2015/08/05 06:00
CRDT- 2014/05/01 06:00
PHST- 2013/10/24 00:00 [received]
PHST- 2014/03/12 00:00 [revised]
PHST- 2014/03/12 00:00 [accepted]
PHST- 2014/05/01 06:00 [entrez]
PHST- 2014/05/02 06:00 [pubmed]
PHST- 2015/08/05 06:00 [medline]
AID - S0387-7604(14)00084-9 [pii]
AID - 10.1016/j.braindev.2014.03.007 [doi]
PST - ppublish
SO  - Brain Dev. 2015 Jan;37(1):88-93. doi: 10.1016/j.braindev.2014.03.007. Epub 2014 
      Apr 26.