PMID- 24780767
OWN - NLM
STAT- MEDLINE
DCOM- 20150113
LR  - 20191210
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 271
DP  - 2014 Jun 20
TI  - Effects of exercise on mitochondrial function, neuroplasticity and 
      anxio-depressive behavior of mice.
PG  - 56-63
LID - S0306-4522(14)00329-7 [pii]
LID - 10.1016/j.neuroscience.2014.04.027 [doi]
AB  - The present study was aimed at analyzing the effects of physical exercise on 
      mitochondrial physiology, anxio-depressive-like behaviors and neuroplasticity in 
      mice. Adult C57BL/6J male mice were isolated in home cages equipped or not with 
      free-running wheels. After 6weeks of exercise, mice were tested in various 
      behavioral paradigms to evaluate anxiety- and depressive-like behaviors. The 
      hippocampi were dissected for neurochemical assays, including mitochondrial 
      activity, monoamines content and the expression of genes involved in energy 
      metabolism and brain-derived neurotrophic factor (BDNF) regulation. Exercise 
      decreased anxiety-like behaviors in the open field and elevated plus maze, and 
      exerted antidepressant-like effects in the tail suspension test. Exercise 
      stimulated brain mitochondrial activity and increased resistance against 
      rotenone, an inhibitor of complex I activity. Furthermore, mRNA expression of 
      Bdnf, Gdnf, Tfam (mitochondrial transcription factor A), and Ndufa6 
      (mitochondrial I subunit) genes, as well as the phosphorylation of cAMP response 
      element-binding protein were increased after exercise. In summary, exercise 
      appears to engage mitochondrial pathways and to potentiate neuroplasticity and 
      might be associated to mood improvement.
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Aguiar, A S Jr
AU  - Aguiar AS Jr
AD  - Departamento de Bioquimica, Universidade Federal de Santa Catarina, UFSC, Centro 
      de Ciencias Biologicas, CCB, Florianopolis, SC 88049-900, Brazil; Departamento de 
      Farmacologia, Universidade Federal de Santa Catarina, UFSC, Centro de Ciencias 
      Biologicas, CCB, Florianopolis, SC 88049-900, Brazil. Electronic address: 
      aderbalaguiar@gmail.com.
FAU - Stragier, E
AU  - Stragier E
AD  - INSERM UMR 894, Centre de Psychiatrie et Neurosciences, CPN, Paris 75634, France; 
      Universite Pierre et Marie Curie, UPMC, Site Pitie-Salpetriere, Paris 75634, 
      France.
FAU - da Luz Scheffer, D
AU  - da Luz Scheffer D
AD  - Departamento de Bioquimica, Universidade Federal de Santa Catarina, UFSC, Centro 
      de Ciencias Biologicas, CCB, Florianopolis, SC 88049-900, Brazil.
FAU - Remor, A P
AU  - Remor AP
AD  - Departamento de Bioquimica, Universidade Federal de Santa Catarina, UFSC, Centro 
      de Ciencias Biologicas, CCB, Florianopolis, SC 88049-900, Brazil.
FAU - Oliveira, P A
AU  - Oliveira PA
AD  - Departamento de Farmacologia, Universidade Federal de Santa Catarina, UFSC, 
      Centro de Ciencias Biologicas, CCB, Florianopolis, SC 88049-900, Brazil.
FAU - Prediger, R D
AU  - Prediger RD
AD  - Departamento de Farmacologia, Universidade Federal de Santa Catarina, UFSC, 
      Centro de Ciencias Biologicas, CCB, Florianopolis, SC 88049-900, Brazil.
FAU - Latini, A
AU  - Latini A
AD  - Departamento de Bioquimica, Universidade Federal de Santa Catarina, UFSC, Centro 
      de Ciencias Biologicas, CCB, Florianopolis, SC 88049-900, Brazil.
FAU - Raisman-Vozari, R
AU  - Raisman-Vozari R
AD  - Universite Pierre et Marie Curie, UPMC, Site Pitie-Salpetriere, Paris 75634, 
      France; INSERM UMR 975, Centre de Recherche de l'Institut du Cerveau et de la 
      Moelle Epiniere, CRICM, Paris 75634, France.
FAU - Mongeau, R
AU  - Mongeau R
AD  - INSERM UMR 894, Centre de Psychiatrie et Neurosciences, CPN, Paris 75634, France; 
      Universite Pierre et Marie Curie, UPMC, Site Pitie-Salpetriere, Paris 75634, 
      France.
FAU - Lanfumey, L
AU  - Lanfumey L
AD  - INSERM UMR 894, Centre de Psychiatrie et Neurosciences, CPN, Paris 75634, France; 
      Universite Pierre et Marie Curie, UPMC, Site Pitie-Salpetriere, Paris 75634, 
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140426
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - EC 7.1.1.2 (Electron Transport Complex I)
SB  - IM
MH  - Animals
MH  - Anxiety/*physiopathology
MH  - Biogenic Monoamines/metabolism
MH  - Brain/drug effects/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/*physiopathology
MH  - Electron Transport Complex I/antagonists & inhibitors/metabolism
MH  - Exploratory Behavior/physiology
MH  - Gene Expression/physiology
MH  - Hippocampus/drug effects/physiopathology
MH  - Housing, Animal
MH  - Male
MH  - Maze Learning/physiology
MH  - Mice, Inbred C57BL
MH  - Mitochondria/drug effects/*physiology
MH  - Motor Activity/*physiology
MH  - Neuronal Plasticity/*physiology
MH  - RNA, Messenger/metabolism
MH  - Social Isolation
MH  - Volition/physiology
OTO - NOTNLM
OT  - depression
OT  - epigenetic
OT  - hippocampus
OT  - mitochondria
OT  - mood
OT  - neurotrophin
EDAT- 2014/05/02 06:00
MHDA- 2015/01/15 06:00
CRDT- 2014/05/01 06:00
PHST- 2014/02/06 00:00 [received]
PHST- 2014/03/28 00:00 [revised]
PHST- 2014/04/17 00:00 [accepted]
PHST- 2014/05/01 06:00 [entrez]
PHST- 2014/05/02 06:00 [pubmed]
PHST- 2015/01/15 06:00 [medline]
AID - S0306-4522(14)00329-7 [pii]
AID - 10.1016/j.neuroscience.2014.04.027 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Jun 20;271:56-63. doi: 10.1016/j.neuroscience.2014.04.027. 
      Epub 2014 Apr 26.