PMID- 24780769
OWN - NLM
STAT- MEDLINE
DCOM- 20150113
LR  - 20140602
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 271
DP  - 2014 Jun 20
TI  - Physical exercise training and neurovascular unit in ischemic stroke.
PG  - 99-107
LID - S0306-4522(14)00332-7 [pii]
LID - 10.1016/j.neuroscience.2014.04.030 [doi]
AB  - Physical exercise could exert a neuroprotective effect in both clinical studies 
      and animal experiments. A series of related studies have indicated that physical 
      exercise could reduce infarct volume, alleviate neurological deficits, decrease 
      blood-brain barrier dysfunction, promote angiogenesis in cerebral vascular system 
      and increase the survival rate after ischemic stroke. In this review, we 
      summarized the protective effects of physical exercise on neurovascular unit 
      (NVU), including neurons, astrocytes, pericytes and the extracellular matrix. 
      Furthermore, it was demonstrated that exercise training could decrease the 
      blood-brain barrier dysfunction and promote angiogenesis in cerebral vascular 
      system. An awareness of the exercise intervention benefits pre- and post stroke 
      may lead more stroke patients and people with high-risk factors to accept 
      exercise therapy for the prevention and treatment of stroke.
CI  - Copyright (c) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Wang, X
AU  - Wang X
AD  - Department of Neurology, The Third Hospital of Hebei Medical University, 
      Shijiazhuang 050051, PR China.
FAU - Zhang, M
AU  - Zhang M
AD  - Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, PR 
      China.
FAU - Feng, R
AU  - Feng R
AD  - Department of Neurology, The Third Hospital of Hebei Medical University, 
      Shijiazhuang 050051, PR China.
FAU - Li, W B
AU  - Li WB
AD  - Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, PR 
      China.
FAU - Ren, S Q
AU  - Ren SQ
AD  - Department of Neurology, The Third Hospital of Hebei Medical University, 
      Shijiazhuang 050051, PR China.
FAU - Zhang, J
AU  - Zhang J
AD  - Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical 
      University, Shijiazhuang 050051, PR China.
FAU - Zhang, F
AU  - Zhang F
AD  - Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical 
      University, Shijiazhuang 050051, PR China; Hebei Provincial Orthopedic 
      Biomechanics Key Laboratory, The Third Hospital of Hebei Medical University, 
      Shijiazhuang 050051, PR China. Electronic address: zjk20019@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140426
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
SB  - IM
MH  - Brain/blood supply/pathology/*physiopathology
MH  - Brain Ischemia/pathology/*physiopathology/*therapy
MH  - Exercise Therapy/*methods
MH  - Humans
MH  - Male
MH  - Stroke/pathology/*physiopathology/*therapy
OTO - NOTNLM
OT  - angiogenesis
OT  - blood-brain barrier (BBB)
OT  - cerebral blood vessels
OT  - neurovascular unit (NVU)
OT  - stroke
EDAT- 2014/05/02 06:00
MHDA- 2015/01/15 06:00
CRDT- 2014/05/01 06:00
PHST- 2014/01/29 00:00 [received]
PHST- 2014/03/16 00:00 [revised]
PHST- 2014/04/09 00:00 [accepted]
PHST- 2014/05/01 06:00 [entrez]
PHST- 2014/05/02 06:00 [pubmed]
PHST- 2015/01/15 06:00 [medline]
AID - S0306-4522(14)00332-7 [pii]
AID - 10.1016/j.neuroscience.2014.04.030 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Jun 20;271:99-107. doi: 10.1016/j.neuroscience.2014.04.030. 
      Epub 2014 Apr 26.