PMID- 24781287
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20190109
IS  - 1532-8651 (Electronic)
IS  - 1098-7339 (Linking)
VI  - 39
IP  - 4
DP  - 2014 Jul-Aug
TI  - High-frequency transcutaneous electrical nerve stimulation attenuates 
      postsurgical pain and inhibits excess substance P in rat dorsal root ganglion.
PG  - 322-8
LID - 10.1097/AAP.0000000000000091 [doi]
AB  - BACKGROUND: Transcutaneous electrical nerve stimulation (TENS) is a common 
      therapeutic modality for pain management, but its effectiveness in skin/muscle 
      incision and retraction (SMIR)-evoked pain is unknown. We aimed to examine the 
      effects of TENS on postoperative pain and the levels of substance P (SP), 
      N-methyl-D-aspartate receptor 1 (NR1), and interleukin 1beta (IL-1beta) in rat dorsal 
      root ganglion (DRG). METHODS: High-frequency (100 Hz) TENS was administered daily 
      beginning on postoperative day 1 (POD1) and continued until animal subjects were 
      killed for tissues. Mechanical sensitivity to von Frey stimuli (6g and 15g) and 
      the levels of NR1, SP, and IL-1beta in DRG were assessed in the sham-operated, 
      SMIR-operated, TENS after SMIR surgery, and placebo-TENS after SMIR surgery 
      groups. RESULTS: Skin/muscle incision and retraction rats exhibited a significant 
      hypersensitivity to von Frey stimuli on POD3. In contrast with SMIR rats, 
      SMIR-operated rats receiving TENS therapy demonstrated a rapid recovery of 
      mechanical hypersensitivity. The SMIR-operated rats showed an up-regulation of 
      NR1, SP, and IL-1beta in DRG on PODs 14 and 28, whereas the SMIR-operated rats after 
      TENS administration reversed this up-regulation. By contrast, the placebo-TENS 
      after SMIR operation did not alter postsurgical pain nor the levels of NR1, SP, 
      and IL-1beta. CONCLUSIONS: Our data demonstrated that TENS intervention reduced 
      persistent postoperative pain caused by SMIR operation. Up-regulation of NR1, SP, 
      and IL-1beta in DRG, activated after SMIR surgery, is important in the development 
      of prolonged postincisional pain. The TENS pain relief may be related to the 
      suppression of NR1, SP, and IL-1beta in DRG of SMIR rats.
FAU - Chen, Yu-Wen
AU  - Chen YW
AD  - From the *Department of Physical Therapy, China Medical University, Taichung; 
      daggerDepartment of Medical Research, Chi-Mei Medical Center; double daggerDepartment of Food 
      Sciences and Technology, Chia Nan University of Pharmacy and Science, Jen-Te; 
       section signDepartment of Anesthesiology, Chi-Mei Medical Center, Yong Kang; and  parallelInstitute 
      and Department of Physical Therapy, National Cheng Kung University, Tainan City, 
      Taiwan.
FAU - Tzeng, Jann-Inn
AU  - Tzeng JI
FAU - Lin, Min-Fei
AU  - Lin MF
FAU - Hung, Ching-Hsia
AU  - Hung CH
FAU - Hsieh, Pei-Ling
AU  - Hsieh PL
FAU - Wang, Jhi-Joung
AU  - Wang JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Reg Anesth Pain Med
JT  - Regional anesthesia and pain medicine
JID - 9804508
RN  - 0 (Interleukin-1beta)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Animals
MH  - Ganglia, Spinal/*metabolism
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Pain Measurement
MH  - Pain, Postoperative/*therapy
MH  - Physical Stimulation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Substance P/*metabolism
MH  - Transcutaneous Electric Nerve Stimulation/*methods
EDAT- 2014/05/02 06:00
MHDA- 2015/02/20 06:00
CRDT- 2014/05/01 06:00
PHST- 2014/05/01 06:00 [entrez]
PHST- 2014/05/02 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - 10.1097/AAP.0000000000000091 [doi]
PST - ppublish
SO  - Reg Anesth Pain Med. 2014 Jul-Aug;39(4):322-8. doi: 10.1097/AAP.0000000000000091.