PMID- 24782729
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140430
LR  - 20211021
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 8
DP  - 2014
TI  - Neuropeptide S and BDNF gene expression in the amygdala are influenced by social 
      decision-making under stress.
PG  - 121
LID - 10.3389/fnbeh.2014.00121 [doi]
LID - 121
AB  - In a newly developed conceptual model of stressful social decision-making, the 
      Stress-Alternatives Model (SAM; used for the 1st time in mice) elicits two types 
      of response: escape or remain submissively. Daily (4d) aggressive social 
      interaction in a neutral arena between a C57BL6/N test mouse and a larger, novel 
      aggressive CD1 mouse, begin after an audible tone (conditioned stimulus; CS). 
      Although escape holes (only large enough for smaller test animals) are available, 
      and the aggressor is unremittingly antagonistic, only half of the mice tested 
      utilize the possibility of escape. During training, for mice that choose to leave 
      the arena and social interaction, latency to escape dramatically decreases over 
      time; this is also true for control C57BL6/N mice which experienced no 
      aggression. Therefore, the open field of the SAM apparatus is intrinsically 
      anxiogenic. It also means that submission to the aggressor is chosen despite this 
      anxiety and the high intensity of the aggressive attacks and defeat. While both 
      groups that received aggression displayed stress responsiveness, corticosterone 
      levels were significantly higher in animals that chose submissive coexistence. 
      Although both escaping and non-escaping groups of animals experienced aggression 
      and defeat, submissive animals also exhibited classic fear conditioning, freezing 
      in response to the CS alone, while escaping animals did not. In the basolateral 
      amygdala (BLA), gene expression of brain-derived neurotrophic factor (BDNF) was 
      diminished, at the same time neuropeptide S (NPS) expression was significantly 
      elevated, but only in submissive animals. This increase in submission-evoked NPS 
      mRNA expression was greatest in the central amygdala (CeA), which coincided with 
      decreased BDNF expression. Reduced expression of BDNF was only found in 
      submissive animals that also exhibit elevated NPS expression, despite elevated 
      corticosterone in all socially interacting animals. The results suggest an 
      interwoven relationship, linked by social context, between amygdalar BDNF, NPS 
      and plasma corticosterone.
FAU - Smith, Justin P
AU  - Smith JP
AD  - Department of Biology, University of South Dakota Vermillion, SD, USA ; 
      Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of 
      Medicine, University of South Dakota Vermillion, SD, USA ; Research Service, 
      Sioux Falls VA Healthcare System Sioux Falls, SD, USA.
FAU - Achua, Justin K
AU  - Achua JK
AD  - Department of Biology, University of South Dakota Vermillion, SD, USA ; 
      Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of 
      Medicine, University of South Dakota Vermillion, SD, USA ; Research Service, 
      Sioux Falls VA Healthcare System Sioux Falls, SD, USA.
FAU - Summers, Tangi R
AU  - Summers TR
AD  - Department of Biology, University of South Dakota Vermillion, SD, USA ; 
      Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of 
      Medicine, University of South Dakota Vermillion, SD, USA.
FAU - Ronan, Patrick J
AU  - Ronan PJ
AD  - Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of 
      Medicine, University of South Dakota Vermillion, SD, USA ; Research Service, 
      Sioux Falls VA Healthcare System Sioux Falls, SD, USA ; Avera Research 
      Institiute, Avera McKennan Hospital and University Health Center Sioux Falls, SD, 
      USA.
FAU - Summers, Cliff H
AU  - Summers CH
AD  - Department of Biology, University of South Dakota Vermillion, SD, USA ; 
      Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of 
      Medicine, University of South Dakota Vermillion, SD, USA.
LA  - eng
GR  - P20 RR015567/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20140408
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC3986560
OTO - NOTNLM
OT  - BDNF
OT  - aggression
OT  - decision-making
OT  - escape
OT  - neuropeptide S
OT  - stress
OT  - submission
EDAT- 2014/05/02 06:00
MHDA- 2014/05/02 06:01
PMCR- 2014/01/01
CRDT- 2014/05/01 06:00
PHST- 2013/11/06 00:00 [received]
PHST- 2014/03/22 00:00 [accepted]
PHST- 2014/05/01 06:00 [entrez]
PHST- 2014/05/02 06:00 [pubmed]
PHST- 2014/05/02 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2014.00121 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2014 Apr 8;8:121. doi: 10.3389/fnbeh.2014.00121. 
      eCollection 2014.