PMID- 24782766
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140430
LR  - 20220409
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 6
DP  - 2014
TI  - A large, cross-sectional observational study of serum BDNF, cognitive function, 
      and mild cognitive impairment in the elderly.
PG  - 69
LID - 10.3389/fnagi.2014.00069 [doi]
LID - 69
AB  - OBJECTIVE: The clinical relationship between brain-derived neurotrophic factor 
      (BDNF) and cognitive function or mild cognitive impairment (MCI) is not 
      well-understood. The purpose of this study was to identify the relationship 
      between serum BDNF and cognitive function and MCI, and determine whether serum 
      BDNF level might be a useful biomarker for assessing risk for MCI in older 
      people. MATERIALS AND METHODS: A total of 4463 individuals aged 65 years or older 
      (mean age 72 years) participating in the study. We measured performance in a 
      battery of neuropsychological and cognitive function tests; serum BDNF 
      concentration. RESULTS: Eight hundred twenty-seven participants (18.8%) had MCI. 
      After adjustment for sex, age, education level, diabetes, and current smoking, 
      serum BDNF was associated with poorer performance in the story memory, and digit 
      symbol substitution task scores. Serum BDNF was marginally associated with the 
      presence of MCI (odds ratio, 95% confidence interval: 1.41, 1.00-1.99) when BDNF 
      was 1.5 SD lower than the mean value standardized for sex and age, education 
      level, diabetes, and current smoking. CONCLUSION: Low serum BDNF was associated 
      with lower cognitive test scores and MCI. Future prospective studies should 
      establish the discriminative value of serum BDNF for the risk of MCI.
FAU - Shimada, Hiroyuki
AU  - Shimada H
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology , Obu , Japan.
FAU - Makizako, Hyuma
AU  - Makizako H
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology , Obu , Japan.
FAU - Doi, Takehiko
AU  - Doi T
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology , Obu , Japan.
FAU - Yoshida, Daisuke
AU  - Yoshida D
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology , Obu , Japan.
FAU - Tsutsumimoto, Kota
AU  - Tsutsumimoto K
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology , Obu , Japan.
FAU - Anan, Yuya
AU  - Anan Y
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology , Obu , Japan.
FAU - Uemura, Kazuki
AU  - Uemura K
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology , Obu , Japan.
FAU - Lee, Sangyoon
AU  - Lee S
AD  - Department of Functioning Activation, Center for Gerontology and Social Science, 
      National Center for Geriatrics and Gerontology , Obu , Japan.
FAU - Park, Hyuntae
AU  - Park H
AD  - Research Institute, National Center for Geriatrics and Gerontology , Obu , Japan.
FAU - Suzuki, Takao
AU  - Suzuki T
AD  - Research Institute, National Center for Geriatrics and Gerontology , Obu , Japan.
LA  - eng
PT  - Journal Article
DEP - 20140415
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC3995061
OTO - NOTNLM
OT  - aged
OT  - biomarker
OT  - brain-derived neurotrophic factor
OT  - cognition
OT  - dementia
EDAT- 2014/05/02 06:00
MHDA- 2014/05/02 06:01
PMCR- 2014/01/01
CRDT- 2014/05/01 06:00
PHST- 2014/01/20 00:00 [received]
PHST- 2014/03/28 00:00 [accepted]
PHST- 2014/05/01 06:00 [entrez]
PHST- 2014/05/02 06:00 [pubmed]
PHST- 2014/05/02 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2014.00069 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2014 Apr 15;6:69. doi: 10.3389/fnagi.2014.00069. 
      eCollection 2014.