PMID- 2478627
OWN - NLM
STAT- MEDLINE
DCOM- 19891130
LR  - 20171116
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 143
IP  - 9
DP  - 1989 Nov 1
TI  - Functional heterogeneity among CD4+ encephalitogenic T cells in recruitment of 
      CD8+ T cells in experimental autoimmune encephalomyelitis.
PG  - 2867-72
AB  - Inoculation of Lewis rats with live or attenuated (irradiated or 
      paraformaldehyde-fixed) CD4+ encephalitogenic T cells (S1 line) protects the 
      recipients from transferred experimental autoimmune encephalomyelitis (tEAE) 
      induced by S1 cells. A CD8+ T lymphocyte population specifically activated 
      against the EAE-inducing S1 cells can be readily isolated from the lymphoid 
      organs of pretreated animals. We show, in the present study, that 
      encephalitogenic T cell lines derived from Lewis rats differ in their ability to 
      induce resistance against tEAE in vivo and to stimulate CD8+ cell proliferation 
      in vitro. We also demonstrate that the S19 line of encephalitogenic T cells, in 
      combination with myelin basic protein (MBP), can stimulate CD8+ cell 
      proliferation in vitro. The CD8+ cells generated in this way strongly suppress 
      MBP-specific T cell proliferation in vitro. This combined effect of T cells and 
      MBP was also evident in vivo. Neither S19 cells nor MBP alone induced resistance 
      against S19-mediated tEAE, rather coinjection of these cells and MBP was 
      required. Our results suggest that resistance to EAE is mediated by distinct 
      populations of encephalitogenic T cells that activate Ts cells through different 
      mechanisms. In some instances, both autoreactive T cells and their relevant 
      autoantigen(s) may be needed to activate Ts cells in vivo.
FAU - Sun, D
AU  - Sun D
AD  - Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 
      38101.
FAU - Klinkert, W E
AU  - Klinkert WE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD8 Antigens)
RN  - 0 (Myelin Basic Protein)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - Antigens, Differentiation, T-Lymphocyte/*immunology
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8 Antigens
MH  - Cell Line
MH  - Cell Membrane/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology
MH  - Immunization, Passive
MH  - Immunologic Techniques
MH  - Lymphocyte Activation
MH  - Myelin Basic Protein/*immunology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - T-Lymphocytes, Regulatory/immunology
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1989 Nov 1;143(9):2867-72.