PMID- 24786842
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 122
IP  - 8
DP  - 2014 Aug
TI  - Gestational weight gain and exposure of newborns to persistent organic 
      pollutants.
PG  - 873-9
LID - 10.1289/ehp.1306758 [doi]
AB  - BACKGROUND: Exposure to persistent organic pollutants (POPs) during fetal 
      development can increase the risk of adverse health effects during childhood. 
      Maternal characteristics and physiological changes during gestation, such as 
      gestational weight gain (GWG), may have an influence in the overall burden of 
      POPs in neonates. However, the associations between GWG and POP concentrations 
      are still not well established. OBJECTIVE: We examined the association of GWG 
      with cord serum POPs concentrations after adjusting for prepregnancy maternal 
      body mass index (BMI) and other potential determinants of the transfer of POPs 
      into newborns. The GWG values were evaluated after grouping by the reference 
      guidelines of the Institute of Medicine (IOM). METHODS: We measured levels of 14 
      organochlorine pesticides, 7 polychlorobiphenyls (PCBs), and 14 polybrominated 
      diphenyl ethers (PBDEs) in 325 cord serum samples from a Spanish birth cohort. 
      Multivariable models were used to estimate associations of GWG, prepregnancy BMI, 
      and other maternal determinants on cord serum concentrations of POPs. RESULTS: 
      Neonatal concentrations of POPs were inversely associated with GWG after 
      adjustment for age, prepregnancy BMI, educational level, and fish consumption. On 
      average, neonates of women with IOM-recommended GWG have lower POP concentrations 
      than do neonates of mothers with inadequate GWG. CONCLUSIONS: The present 
      findings suggest an association between neonatal exposure to POPs and inadequate 
      GWG during pregnancy. Encouraging pregnant women to meet the recommended IOM 
      guidelines for GWG may reduce the accumulation of POPs in newborns.
FAU - Vizcaino, Esther
AU  - Vizcaino E
AD  - Department of Preventive Medicine and Public Health, University of Oviedo, 
      Asturias, Spain.
FAU - Grimalt, Joan O
AU  - Grimalt JO
FAU - Glomstad, Berit
AU  - Glomstad B
FAU - Fernandez-Somoano, Ana
AU  - Fernandez-Somoano A
FAU - Tardon, Adonina
AU  - Tardon A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140502
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Fetal Development
MH  - Humans
MH  - Hydrocarbons, Chlorinated/toxicity
MH  - Infant, Newborn
MH  - Maternal Exposure/adverse effects
MH  - Polychlorinated Biphenyls/toxicity
MH  - Pregnancy
MH  - Weight Gain/*drug effects
PMC - PMC4123021
COIS- The authors alone are responsible for the content and writing of the paper. The 
      authors declare they have no actual or potential competing financial interests.
EDAT- 2014/05/03 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/08/01
CRDT- 2014/05/03 06:00
PHST- 2013/03/05 00:00 [received]
PHST- 2014/05/01 00:00 [accepted]
PHST- 2014/05/03 06:00 [entrez]
PHST- 2014/05/03 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - ehp.1306758 [pii]
AID - 10.1289/ehp.1306758 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2014 Aug;122(8):873-9. doi: 10.1289/ehp.1306758. Epub 
      2014 May 2.