PMID- 24786929
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20161125
IS  - 1499-2752 (Electronic)
IS  - 0315-162X (Linking)
VI  - 41
IP  - 6
DP  - 2014 Jun
TI  - Discrepancy between clinical and radiological responses to tocilizumab treatment 
      in patients with systemic-onset juvenile idiopathic arthritis.
PG  - 1171-7
LID - 10.3899/jrheum.130924 [doi]
AB  - OBJECTIVE: Tocilizumab (TCZ), an antiinterleukin-6 receptor monoclonal antibody, 
      is clinically beneficial in patients with systemic-onset juvenile idiopathic 
      arthritis (sJIA). We investigated the clinical and radiological outcomes of TCZ 
      therapy in patients with sJIA. METHODS: We retrospectively evaluated 2 clinical 
      trials (NCT00144599 and NCT00144612) involving 40 patients with sJIA who received 
      intravenous TCZ (8 mg/kg) every 2 weeks. Clinical data and radiographs of the 
      hands and large joints were assessed before and during TCZ treatment. The 
      Poznanski score, modified Larsen scores of the hands and large joints, and 
      Childhood Arthritis Radiographic Score of the Hip (CARSH) were recorded. RESULTS: 
      After a mean duration of 4.5 years of TCZ treatment, clinical data had improved 
      significantly, the mean Poznanski score improved from -1.5 to -1.1, the mean 
      Larsen score of the hands deteriorated from 7.0 to 10.0, the mean Larsen score 
      for the large joints deteriorated from 5.9 to 6.8, and the CARSH worsened from 
      3.9 to 6.2. The Larsen score for the large joints improved in 11 cases (28%), 
      remained unchanged in 8 cases (20%), and worsened in 21 cases (52%). Matrix 
      metalloproteinase 3 (MMP-3) levels remained significantly higher (278 mg/dl) in 
      patients with worsened Larsen scores than in patients with improved or unchanged 
      scores (65 mg/dl). Logistic regression analysis showed that older age at disease 
      onset was a significant risk factor for radiographic progression. CONCLUSION: The 
      modified Larsen score of the large joints deteriorated in half the patients who 
      had high MMP-3 levels during TCZ treatment and who were significantly older at 
      disease onset.
FAU - Aoki, Chie
AU  - Aoki C
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
FAU - Inaba, Yutaka
AU  - Inaba Y
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University. 
      yute0131@med.yokohama-cu.ac.jp.
FAU - Choe, Hyonmin
AU  - Choe H
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
FAU - Kaneko, Utako
AU  - Kaneko U
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
FAU - Hara, Ryoki
AU  - Hara R
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
FAU - Miyamae, Takako
AU  - Miyamae T
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
FAU - Imagawa, Tomoyuki
AU  - Imagawa T
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
FAU - Mori, Masaaki
AU  - Mori M
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
FAU - Oba, Mari S
AU  - Oba MS
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
FAU - Yokota, Shumpei
AU  - Yokota S
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
FAU - Saito, Tomoyuki
AU  - Saito T
AD  - From the Department of Orthopedic Surgery, the Department of Pediatrics, and the 
      Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, 
      Japan.C. Aoki, MD; Y. Inaba, MD, PhD, Associate Professor; H. Choe, MD, PhD, 
      Department of Orthopedic Surgery; U. Kaneko, MD; R. Hara, MD, PhD; T. Miyamae, 
      MD, PhD; T. Imagawa, MD, PhD; M. Mori, MD, PhD, Associate Professor, Department 
      of Pediatrics; M.S. Oba, Department of Biostatistics and Epidemiology; S. Yokota, 
      MD, Professor of Pediatrics, Department of Pediatrics; T. Saito, MD, Professor of 
      Orthopedics, Department of Orthopedic Surgery, Yokohama City University.
LA  - eng
SI  - ClinicalTrials.gov/NCT00144599
SI  - ClinicalTrials.gov/NCT00144612
PT  - Clinical Trial
PT  - Journal Article
DEP - 20140501
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antirheumatic Agents)
RN  - I031V2H011 (tocilizumab)
SB  - IM
EIN - J Rheumatol. 2014 Jul;41(7):1567
MH  - Adolescent
MH  - Antibodies, Monoclonal, Humanized/pharmacology/*therapeutic use
MH  - Antirheumatic Agents/pharmacology/*therapeutic use
MH  - Arthritis, Juvenile/diagnostic imaging/*drug therapy
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Hand Joints/*diagnostic imaging/drug effects
MH  - Hip Joint/*diagnostic imaging/drug effects
MH  - Humans
MH  - Male
MH  - Radiography
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Treatment Outcome
OTO - NOTNLM
OT  - HIP JOINT
OT  - LARSEN SCORE
OT  - POZNANSKI SCORE
OT  - RADIOGRAPHY
OT  - SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS
OT  - TOCILIZUMAB
EDAT- 2014/05/03 06:00
MHDA- 2015/02/20 06:00
CRDT- 2014/05/03 06:00
PHST- 2014/05/03 06:00 [entrez]
PHST- 2014/05/03 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - jrheum.130924 [pii]
AID - 10.3899/jrheum.130924 [doi]
PST - ppublish
SO  - J Rheumatol. 2014 Jun;41(6):1171-7. doi: 10.3899/jrheum.130924. Epub 2014 May 1.