PMID- 24787568
OWN - NLM
STAT- MEDLINE
DCOM- 20140729
LR  - 20140819
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 6
DP  - 2014 May 1
TI  - Morphology of retinal vessels in patients with optic nerve head drusen and optic 
      disc edema.
PG  - 3484-90
LID - 10.1167/iovs.14-13903 [doi]
AB  - PURPOSE: We quantitatively investigated the peripapillary vascular morphology in 
      patients with optic nerve head drusen (ONHD) and optic disc edema (ODE). METHODS: 
      Computer-based fundus analysis was used to investigate peripapillary vascular 
      morphology, including length, branching, and diameter of arteries and veins 
      calibrated by optical coherence tomography. RESULTS: Patients with ONHD showed 
      significantly larger diameters of arteries without branching (P = 0.05), and 
      arteries after primary/before secondary branching (P = 0.04) and secondary venous 
      branching started closer to the optic disc (P = 0.03) compared to healthy 
      controls. The ODE patients had significantly reduced number of small 
      peripapillary veins and larger number of veins without branching compared to ONHD 
      and controls (P = 0.02). Anomalous branching with arterial and venous 
      trifurcation presented in the ODE and ONHD groups, with significant higher 
      prevalence in ODE patients for venous trifurcations compared to ONHD and controls 
      (P = 0.02). CONCLUSIONS: The diameter of vessels in ONHD patients were 
      significantly larger in arteries without branching (P = 0.05), after primary 
      branching (P = 0.04), and venous branching closer to the disc area (P = 0.03) 
      compared to controls. The ODE patients demonstrated widening of the small 
      peripapillary veins measured by a significantly larger number of veins without 
      branching (P = 0.001 and P = 0.02, compared to controls and ONHD, respectively) 
      and less small veins (P = 0.001 and P = 0.04, compared to controls and ONHD, 
      respectively).
CI  - Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Pilat, Anastasia V
AU  - Pilat AV
AD  - Ophthalmology Group, University of Leicester, Leicester, United Kingdom.
FAU - Proudlock, Frank A
AU  - Proudlock FA
AD  - Ophthalmology Group, University of Leicester, Leicester, United Kingdom.
FAU - McLean, Rebecca J
AU  - McLean RJ
AD  - Ophthalmology Group, University of Leicester, Leicester, United Kingdom.
FAU - Lawden, Mark C
AU  - Lawden MC
AD  - Department of Neurology, University Hospitals of Leicester, Leicester, United 
      Kingdom.
FAU - Gottlob, Irene
AU  - Gottlob I
AD  - Ophthalmology Group, University of Leicester, Leicester, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140501
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Optic Disk/blood supply/*pathology
MH  - Optic Disk Drusen/*diagnosis
MH  - Papilledema/*diagnosis
MH  - Prospective Studies
MH  - Retinal Vessels/*pathology
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - optic disc drusen
OT  - optic disc edema
OT  - retinal vessels
EDAT- 2014/05/03 06:00
MHDA- 2014/07/30 06:00
CRDT- 2014/05/03 06:00
PHST- 2014/05/03 06:00 [entrez]
PHST- 2014/05/03 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - iovs.14-13903 [pii]
AID - 10.1167/iovs.14-13903 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 May 1;55(6):3484-90. doi: 10.1167/iovs.14-13903.