PMID- 24788172
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20171116
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 1155
DP  - 2014
TI  - Regulation of human dendritic cell functions by natural anti-CD40 antibodies.
PG  - 47-54
LID - 10.1007/978-1-4939-0669-7_5 [doi]
AB  - Dendritic cells (DCs) are professional antigen presenting cells that play a 
      pivotal role in the initiation of immune responses. DCs ingest antigens and then 
      present these antigens to T cells to initiate T cell activation and polarization. 
      DCs receive signals both from environment and from endogenous molecules. DCs in 
      the immune system constantly interact with immunoglobulins (or antibodies) and a 
      substantial amount of these immunoglobulins are natural. We found that natural 
      antibodies have a key role in regulating the DC functions and that CD40-reactive 
      natural antibodies constitute one of the endogenous molecules that provide 
      maturation-associated signals to DCs in physiology. In this chapter, we describe 
      the isolation of anti-CD40 natural antibodies from pooled normal immunoglobulin 
      preparations (intravenous immunoglobulin, IVIg) and their biological effects on 
      human DC maturation and functions.
FAU - Elluru, Sri Ramulu
AU  - Elluru SR
AD  - Singapore Immunology Network, Agency for Science Technology and Research 
      (A*STAR), Singapore, Singapore.
FAU - Kaveri, Srini V
AU  - Kaveri SV
FAU - Bayry, Jagadeesh
AU  - Bayry J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (CD40 Antigens)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Antibodies, Monoclonal/blood/*pharmacology
MH  - Antigen-Presenting Cells/*immunology
MH  - CD40 Antigens/*immunology
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Dendritic Cells/*cytology/drug effects/immunology
MH  - Enzyme-Linked Immunosorbent Assay/*methods
MH  - Humans
MH  - Immunoglobulins, Intravenous/immunology/*metabolism
MH  - Monocytes/*cytology/drug effects/immunology
EDAT- 2014/05/03 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/05/03 06:00
PHST- 2014/05/03 06:00 [entrez]
PHST- 2014/05/03 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/978-1-4939-0669-7_5 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2014;1155:47-54. doi: 10.1007/978-1-4939-0669-7_5.