PMID- 24789704
OWN - NLM
STAT- MEDLINE
DCOM- 20141217
LR  - 20211116
IS  - 1791-2431 (Electronic)
IS  - 1021-335X (Linking)
VI  - 31
IP  - 6
DP  - 2014 Jun
TI  - Protein tyrosine kinase 7 plays a tumor suppressor role by inhibiting ERK and AKT 
      phosphorylation in lung cancer.
PG  - 2708-12
LID - 10.3892/or.2014.3164 [doi]
AB  - Protein tyrosine kinase 7 (PTK7) is a catalytically inactive receptor tyrosine 
      kinase that is also known as colon carcinoma kinase-4 (CCK-4). Recent reports 
      have shown that PTK7 plays an important role in carcinogenesis, and it is known 
      to be upregulated in gastric, colon and esophageal cancer, as well as in 
      liposarcoma. However, the role of PTK7 in lung cancer has not been investigated. 
      The aim of the present study was to investigate the expression levels and the 
      role of PTK7 in lung cancer. We found that PTK7 expression was downregulated at 
      the mRNA as well as protein levels in human lung squamous cell carcinoma (LSCC). 
      Upon investigation of the functional role of PTK7 in LSCC, we found that 
      overexpression of PTK7 in LSCC cells resulted in inhibition of cell 
      proliferation, invasion and migration. Furthermore, we confirmed that these 
      phenotypic changes are associated with the inactivation of AKT and ERK. Our 
      findings suggest that PTK7 has different oncogenic roles in organs and target 
      tumors.
FAU - Kim, Ji-Hee
AU  - Kim JH
AD  - Department of Translational Research, Korea Cancer Center Hospital, Korea 
      Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
FAU - Kwon, Junhye
AU  - Kwon J
AD  - Department of Translational Research, Korea Cancer Center Hospital, Korea 
      Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
FAU - Lee, Hae Won
AU  - Lee HW
AD  - Department of Thoracic Surgery, Korea Cancer Center Hospital, Korea Institute of 
      Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
FAU - Kang, Moon Chul
AU  - Kang MC
AD  - Department of Thoracic Surgery, Korea Cancer Center Hospital, Korea Institute of 
      Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
FAU - Yoon, Hyeon-Joon
AU  - Yoon HJ
AD  - Department of Translational Research, Korea Cancer Center Hospital, Korea 
      Institute of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
FAU - Lee, Seung-Taek
AU  - Lee ST
AD  - Department of Biochemistry, College of Life Science and Biotechnology, Yonsei 
      University, Seoul 120-749, Republic of Korea.
FAU - Park, Jong Ho
AU  - Park JH
AD  - Department of Thoracic Surgery, Korea Cancer Center Hospital, Korea Institute of 
      Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140430
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Cell Adhesion Molecules)
RN  - EC 2.7.10.1 (PTK7 protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.11.1 (Oncogene Protein v-akt)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Carcinogenesis/genetics
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Adhesion Molecules/*biosynthesis/genetics
MH  - Cell Line, Tumor
MH  - Extracellular Signal-Regulated MAP Kinases/genetics/*metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lung Neoplasms/*genetics/pathology
MH  - Oncogene Protein v-akt/*genetics/metabolism
MH  - Phosphorylation
MH  - Receptor Protein-Tyrosine Kinases/*biosynthesis/genetics
EDAT- 2014/05/03 06:00
MHDA- 2014/12/18 06:00
CRDT- 2014/05/03 06:00
PHST- 2014/01/29 00:00 [received]
PHST- 2014/04/09 00:00 [accepted]
PHST- 2014/05/03 06:00 [entrez]
PHST- 2014/05/03 06:00 [pubmed]
PHST- 2014/12/18 06:00 [medline]
AID - 10.3892/or.2014.3164 [doi]
PST - ppublish
SO  - Oncol Rep. 2014 Jun;31(6):2708-12. doi: 10.3892/or.2014.3164. Epub 2014 Apr 30.