PMID- 24789803
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20190221
IS  - 0003-4894 (Print)
IS  - 0003-4894 (Linking)
VI  - 123
IP  - 10
DP  - 2014 Oct
TI  - Notch1 overexpression associates with poor prognosis in human laryngeal squamous 
      cell carcinoma.
PG  - 705-10
LID - 10.1177/0003489414532784 [doi]
AB  - OBJECTIVE: This study aimed to investigate the expression of Notch1 in human 
      laryngeal squamous cell carcinoma (LSCC) tissues and its relationship to 
      clinicopathologic characteristics as well as their prognostic value in LSCC. 
      METHODS: Samples from 106 patients with LSCC were analyzed for Notch1 expression 
      by immunohistochemical staining. The relationship between Notch1 expression and 
      clinicopathologic parameters was subsequently analyzed. Univariate analysis and 
      multivariate analysis of patient survival were examined using the Kaplan-Meier 
      method and Cox proportional hazards model, respectively. RESULTS: We found that 
      Notch1 had positive expression in 71 of 106 cases of LSCC (66.98%), which was 
      obviously higher than laryngeal normal tissues (P < .01) and significantly 
      correlated with the clinical stage, lymph node metastasis, and histological grade 
      (all Ps < .05). Univariate analysis revealed that Notch1 expression tended to 
      show an unfavorable influence on overall survival (OS) and disease-free survival 
      (DFS) (both Ps < .01). Multivariate analysis demonstrated that Notch1 was an 
      independent prognostic factor for patients with LSCC (P < .05). CONCLUSION: These 
      results reveal that Notch1 expression is a potential prognostic factor for 
      malignant progression, metastasis, and survival of LSCC patients. Furthermore, it 
      has been demonstrated that high expression of Notch1 was associated with 
      unfavorable OS and DFS in LSCC patients.
CI  - (c) The Author(s) 2014.
FAU - Li, Dawei
AU  - Li D
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye and ENT 
      Hospital of Fudan University, Shanghai, China.
FAU - Dong, Pin
AU  - Dong P
AD  - Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiaotong University 
      Affiliated First People's Hospital, Shanghai, China.
FAU - Wu, Chunping
AU  - Wu C
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye and ENT 
      Hospital of Fudan University, Shanghai, China.
FAU - Cao, Pengyu
AU  - Cao P
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye and ENT 
      Hospital of Fudan University, Shanghai, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye and ENT 
      Hospital of Fudan University, Shanghai, China zhouliang_lidawei@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140501
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (NOTCH1 protein, human)
RN  - 0 (Receptor, Notch1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Disease-Free Survival
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/mortality/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Receptor, Notch1/*metabolism
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Survival Rate
OTO - NOTNLM
OT  - Notch1
OT  - immunohistochemistry
OT  - laryngeal neoplasms
OT  - prognosis
EDAT- 2014/05/03 06:00
MHDA- 2015/02/20 06:00
CRDT- 2014/05/03 06:00
PHST- 2014/05/03 06:00 [entrez]
PHST- 2014/05/03 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - 0003489414532784 [pii]
AID - 10.1177/0003489414532784 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2014 Oct;123(10):705-10. doi: 10.1177/0003489414532784. 
      Epub 2014 May 1.