PMID- 24789904
OWN - NLM
STAT- MEDLINE
DCOM- 20150106
LR  - 20220129
IS  - 1471-2954 (Electronic)
IS  - 0962-8452 (Print)
IS  - 0962-8452 (Linking)
VI  - 281
IP  - 1785
DP  - 2014 Jun 22
TI  - Trans-generational immune priming in honeybees.
PG  - 20140454
LID - 10.1098/rspb.2014.0454 [doi]
LID - 20140454
AB  - Maternal immune experience acquired during pathogen exposure and passed on to 
      progeny to enhance resistance to infection is called trans-generational immune 
      priming (TgIP). In eusocial insects like honeybees, TgIP would result in a 
      significant improvement of health at individual and colony level. Demonstrated in 
      invertebrates other than honeybees, TgIP has not yet been fully elucidated in 
      terms of intensity and molecular mechanisms underlying this response. Here, we 
      immune-stimulated honeybee queens with Paenibacillus larvae (Pl), a spore-forming 
      bacterium causing American Foulbrood, the most deadly bee brood disease 
      worldwide. Subsequently, offspring of stimulated queens were exposed to spores of 
      Pl and mortality rates were measured to evaluate maternal transfer of immunity. 
      Our data substantiate the existence of TgIP effects in honeybees by direct 
      evaluation of offspring resistance to bacterial infection. A further aspect of 
      this study was to investigate a potential correlation between immune priming 
      responses and prohaemocytes-haemocyte differentiation processes in larvae. The 
      results point out that a priming effect triggers differentiation of prohaemocytes 
      to haemocytes. However, the mechanisms underlying TgIP responses are still 
      elusive and require future investigation.
FAU - Hernandez Lopez, Javier
AU  - Hernandez Lopez J
AD  - Department of Zoology, Karl-Franzens University of Graz, , Universitatsplatz 2, 
      8010 Graz, Austria.
FAU - Schuehly, Wolfgang
AU  - Schuehly W
FAU - Crailsheim, Karl
AU  - Crailsheim K
FAU - Riessberger-Galle, Ulrike
AU  - Riessberger-Galle U
LA  - eng
GR  - P 20510/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140430
PL  - England
TA  - Proc Biol Sci
JT  - Proceedings. Biological sciences
JID - 101245157
SB  - IM
MH  - Animals
MH  - Bees/*genetics/growth & development/*immunology/microbiology
MH  - *Epigenesis, Genetic
MH  - Female
MH  - *Immunity, Innate
MH  - Larva/genetics/immunology/microbiology
MH  - Longevity
MH  - Paenibacillus/*physiology
MH  - Seasons
PMC - PMC4024302
OTO - NOTNLM
OT  - Paenibacillus larvae
OT  - artificial rearing
OT  - haemocytes
OT  - honeybees
OT  - immune priming
EDAT- 2014/05/03 06:00
MHDA- 2015/01/07 06:00
PMCR- 2014/06/22
CRDT- 2014/05/03 06:00
PHST- 2014/05/03 06:00 [entrez]
PHST- 2014/05/03 06:00 [pubmed]
PHST- 2015/01/07 06:00 [medline]
PHST- 2014/06/22 00:00 [pmc-release]
AID - rspb.2014.0454 [pii]
AID - rspb20140454 [pii]
AID - 10.1098/rspb.2014.0454 [doi]
PST - epublish
SO  - Proc Biol Sci. 2014 Apr 30;281(1785):20140454. doi: 10.1098/rspb.2014.0454. Print 
      2014 Jun 22.