PMID- 24790742
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140505
LR  - 20211021
IS  - 2075-051X (Print)
IS  - 2075-0528 (Electronic)
IS  - 2075-051X (Linking)
VI  - 14
IP  - 2
DP  - 2014 May
TI  - Comparison between Three Different Equations for the Estimation of Glomerular 
      Filtration Rate in Omani Patients with Type 2 Diabetes Mellitus.
PG  - e197-203
AB  - OBJECTIVES: Estimated glomerular filtration rate (eGFR) is an important component 
      of a patient's renal function profile. The Modification of Diet in Renal Disease 
      (MDRD) equation and the Chronic Kidney Disease-Epidemiology Collaboration 
      (CKD-EPI) equation are both commonly used. The aim of this study was to compare 
      the performance of the original MDRD186, revised MDRD175 and CKD-EPI equations in 
      calculating eGFR in type 2 diabetes mellitus (T2DM) patients in Oman. METHODS: 
      The study included 607 T2DM patients (275 males and 332 females, mean age +/- 
      standard deviation 56 +/- 12 years) who visited primary health centres in Muscat, 
      Oman, during 2011 and whose renal function was assessed based on serum creatinine 
      measurements. The eGFR was calculated using the three equations and the patients 
      were classified based on chronic kidney disease (CKD) stages according to the 
      National Kidney Foundation Kidney Disease Outcomes Quality Initiative guidelines. 
      A performance comparison was undertaken using the weighted kappa test. RESULTS: 
      The median eGFR (mL/min/1.73 m(2)) was 92.9 for MDRD186, 87.4 for MDRD175 and 
      93.7 for CKD-EPI. The prevalence of CKD stage 1 was 55.4%, 44.7% and 57% while 
      for stages 2 and 3 it was 43.2%, 54% and 41.8%, based on MDRD186, MDRD175 and 
      CKD-EPI, respectively. The agreement between MDRD186 and CKD-EPI (small ka, Cyrillic 0.868) was 
      stronger than MDRD186 and MDRD175 (small ka, Cyrillic 0.753) and MDRD175 and CKD-EPI (small ka, Cyrillic 0.730). 
      CONCLUSION: The performances of MDRD186 and CKD-EPI were comparable. Considering 
      that CKD-EPI-based eGFR is known to be close to isotopically measured GFR, the 
      use of MDRD186 rather than MDRD175 may be recommended.
FAU - Al-Maqbali, Salima R S
AU  - Al-Maqbali SR
AD  - Department of Laboratory Medicine, Sohar Hospital, Sohar, Oman.
FAU - Mula-Abed, Waad-Allah S
AU  - Mula-Abed WA
AD  - Department of Laboratory Medicine, Sohar Hospital, Sohar, Oman.
LA  - eng
PT  - Journal Article
DEP - 20140407
PL  - Oman
TA  - Sultan Qaboos Univ Med J
JT  - Sultan Qaboos University medical journal
JID - 101519915
PMC - PMC3997536
OTO - NOTNLM
OT  - Chronic Renal Insufficiency
OT  - Collaboration
OT  - Diet Modification
OT  - Epidemiology
OT  - Glomerular Filtration Rates
OT  - Oman
OT  - Type 2 Diabetes Mellitus
EDAT- 2014/05/03 06:00
MHDA- 2014/05/03 06:01
PMCR- 2014/05/01
CRDT- 2014/05/03 06:00
PHST- 2013/07/07 00:00 [received]
PHST- 2013/11/11 00:00 [revised]
PHST- 2013/12/30 00:00 [revised]
PHST- 2014/01/16 00:00 [accepted]
PHST- 2014/05/03 06:00 [entrez]
PHST- 2014/05/03 06:00 [pubmed]
PHST- 2014/05/03 06:01 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - squmj1402-e197-203 [pii]
PST - ppublish
SO  - Sultan Qaboos Univ Med J. 2014 May;14(2):e197-203. Epub 2014 Apr 7.