PMID- 24791843
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20191112
IS  - 2066-8643 (Electronic)
IS  - 1844-4172 (Linking)
VI  - 16
IP  - 2
DP  - 2014 Jun
TI  - Comparison between the M and XL probes for liver fibrosis assessment by transient 
      elastography.
PG  - 119-22
AB  - OBJECTIVE: Liver stiffness measurement (LSM) using Transient Elastography (TE) 
      for liver fibrosis assessment is difficult to be performed in obese and 
      overweight patients by standard M probe, thus the XL probe was developed. The aim 
      of our paper was to assess the usefulness of the XL probe in daily clinical 
      practice. MATERIAL AND METHOD: Our study included 216 patients (mean BMI 
      30.1+/-4.1 kg/m2) with chronic hepatopathies, in which paired measurements were 
      made using the M (3.5MHz) and XL (2.5 MHz) probes in the same session. In each 
      patient 10 valid LSM were acquired with each probe, a median was calculated, 
      expressed in kiloPascals (kPa). Unreliable TE measurements were considered: fewer 
      than 10 valid shots; with a success rate (SR) <60% and/or interquartile range 
      interval (IQR) >/=30%. RESULTS: In 127 patients reliable LSM could not be obtained 
      by standard M probe, 10 of them normal weight, 25 of them overweight, and 92 
      obese. By XL probe reliable measurements were obtained in 80/127(63%) of these 
      patients: 8/10 (80%) of the normal weights, 17/25 (68%) of the overweight and 
      55/92 (59.8%) of the obese. In 98 patients with reliable M probe measurements, XL 
      probe LSMs were also performed. XL LS values strongly and significantly 
      correlated with those obtained by M probe (Spearman r=0.789, p<0.0001), but were 
      significantly lower [median 6.4 kPa (range 3.1 - 53.8) vs 7.7 kPa (range 
      3.7-69.1), Wilcoxon paired t test p<0.001)]. CONCLUSION: By using the XL probe, 
      reliable LSM by TE can be obtained in more than 60% of patients with unreliable 
      measurements by M probe. LSM by XL probe are significantly correlated, but lower, 
      than those obtained by M probe.
FAU - Sirli, Roxana
AU  - Sirli R
AD  - Department of Gastroenterology and Hepatology, "Victor Babes" University and 
      Medicine Timisoara, Romania. roxanasirli@gmail.com.
FAU - Sporea, Ioan
AU  - Sporea I
AD  - Department of Gastroenterology and Hepatology, "Victor Babes" University and 
      Medicine Timisoara, Romania.
FAU - Deleanu, Alexandra
AU  - Deleanu A
AD  - Department of Gastroenterology and Hepatology, "Victor Babes" University and 
      Medicine Timisoara, Romania.
FAU - Culcea, Laura
AU  - Culcea L
AD  - Department of Gastroenterology and Hepatology, "Victor Babes" University and 
      Medicine Timisoara, Romania.
FAU - Szilaski, Milana
AU  - Szilaski M
AD  - Department of Gastroenterology and Hepatology, "Victor Babes" University and 
      Medicine Timisoara, Romania.
FAU - Popescu, Alina
AU  - Popescu A
AD  - Department of Gastroenterology and Hepatology, "Victor Babes" University and 
      Medicine Timisoara, Romania.
FAU - Danila, Mirela
AU  - Danila M
AD  - Department of Gastroenterology and Hepatology, "Victor Babes" University and 
      Medicine Timisoara, Romania.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Romania
TA  - Med Ultrason
JT  - Medical ultrasonography
JID - 101522985
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Elasticity Imaging Techniques/*instrumentation
MH  - Equipment Design
MH  - Female
MH  - Hepatitis B, Chronic/diagnostic imaging
MH  - Hepatitis C, Chronic/diagnostic imaging
MH  - Humans
MH  - Liver/diagnostic imaging
MH  - Liver Cirrhosis/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/diagnostic imaging
MH  - Obesity/diagnostic imaging
MH  - Overweight/diagnostic imaging
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Transducers
EDAT- 2014/05/06 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/05/06 06:00
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.11152/mu.201.3.2066.162.rs1is2 [doi]
PST - ppublish
SO  - Med Ultrason. 2014 Jun;16(2):119-22. doi: 10.11152/mu.201.3.2066.162.rs1is2.