PMID- 24792107
OWN - NLM
STAT- MEDLINE
DCOM- 20141014
LR  - 20220321
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 158
IP  - 2
DP  - 2014 Aug
TI  - Spectral-domain optical coherence tomography epithelial and flap thickness 
      mapping in femtosecond laser-assisted in situ keratomileusis.
PG  - 293-301.e1
LID - S0002-9394(14)00215-3 [pii]
LID - 10.1016/j.ajo.2014.04.012 [doi]
AB  - PURPOSE: To evaluate the change of epithelial and flap thickness after 
      femtosecond laser-assisted in situ keratomileusis (LASIK) using spectral-domain 
      optical coherence tomography (SD OCT) in correlation with the spherical 
      equivalent refraction treated and clinical outcomes. DESIGN: Prospective, 
      randomized, contralateral-eye study. METHODS: Forty myopic eyes underwent LASIK 
      using an excimer laser with refraction ranging from -1.00 to -7.25 diopters (mean 
      -3.25+/-1.9). Flap creation was randomized between eyes, using the IntraLASE FS60 
      laser (IL) in 1 eye and WaveLight FS200 laser (FS) in the contralateral eye. SD 
      OCT was used to evaluate the epithelial and flap thickness profiles and corneal 
      power preoperatively and at 1 week and 1, 3, and 9 months postoperatively. 
      Manifest and wavefront refractions were performed at each postoperative visit. 
      RESULTS: Statistically significant epithelial thickening was observed in both IL 
      and FS groups as early as 1 month postoperatively (P=.033 and P=.042), but this 
      stabilized between 3 (P=.042 and P=.035) and 9 months (P=.043 and P=.041). 
      Femtosecond-LASIK flaps were thicker in the IL group in comparison to the FS 
      group at 3 and 9 months postoperatively (P=.003 and P=.005, respectively). There 
      was a statistically significant correlation between the magnitude of preoperative 
      myopic refraction and the central epithelial thickness at 1, 3, and 9 months 
      (Pearson correlation coefficients 0.485, 0.587 and 0.576) (P=.0021, P=.0010, and 
      P=.0011), respectively. SD OCT corneal power maps showed steepening at 3 and 9 
      months along with mild myopic shift. CONCLUSION: Progressive epithelial and flap 
      thickening with increased corneal power were observed after femtosecond 
      laser-assisted in situ keratomileusis for myopia with consequent stabilization 
      between 3 to 9 months postoperatively. The magnitude of epithelial and flap 
      thickness remodeling correlated to the preoperative myopic refractive error.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Rocha, Karolinne Maia
AU  - Rocha KM
AD  - Cleveland Clinic Foundation - Cole Eye Institute, Cleveland, Ohio. Electronic 
      address: karolinnemaia@gmail.com.
FAU - Krueger, Ronald R
AU  - Krueger RR
AD  - Cleveland Clinic Foundation - Cole Eye Institute, Cleveland, Ohio.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140430
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
CIN - Am J Ophthalmol. 2015 Feb;159(2):405-6. PMID: 25542555
CIN - Am J Ophthalmol. 2015 Feb;159(2):405. PMID: 25542556
MH  - Adult
MH  - Cornea/*pathology/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Keratomileusis, Laser In Situ/*methods
MH  - Male
MH  - Myopia/pathology/physiopathology/*surgery
MH  - Prospective Studies
MH  - *Refraction, Ocular
MH  - Reproducibility of Results
MH  - Surgical Flaps/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Treatment Outcome
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2014/05/06 06:00
MHDA- 2014/10/15 06:00
CRDT- 2014/05/06 06:00
PHST- 2013/12/15 00:00 [received]
PHST- 2014/04/14 00:00 [revised]
PHST- 2014/04/15 00:00 [accepted]
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2014/10/15 06:00 [medline]
AID - S0002-9394(14)00215-3 [pii]
AID - 10.1016/j.ajo.2014.04.012 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2014 Aug;158(2):293-301.e1. doi: 10.1016/j.ajo.2014.04.012. Epub 
      2014 Apr 30.