PMID- 24792334
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20220408
IS  - 1872-8332 (Electronic)
IS  - 0169-5002 (Linking)
VI  - 85
IP  - 1
DP  - 2014 Jul
TI  - The role of (18)F-FDG PET/CT for evaluation of metastatic mediastinal lymph nodes 
      in patients with lung squamous-cell carcinoma or adenocarcinoma.
PG  - 53-8
LID - S0169-5002(14)00171-8 [pii]
LID - 10.1016/j.lungcan.2014.04.004 [doi]
AB  - OBJECTIVES: To evaluate the efficacy of (18)F-FDG PET/CT in depicting metastatic 
      mediastinal lymph nodes in patients with lung squamous-cell carcinoma (LSCC) or 
      lung adenocarcinoma (LAC) in a tuberculosis-endemic country. METHODS: This study 
      retrospectively reviewed patients with LSCC or LAC, who underwent preoperative 
      (18)F-FDG PET/CT to assess mediastinal lymph node metastasis. Patients with the 
      short-axis of mediastinal lymph node</=15mm were included. PET/CT interpretation 
      was analyzed in two ways. Firstly, with CT for anatomical localization, lymph 
      nodes showing greater (18)F-FDG uptake than vessel pool on PET were regarded 
      malignant. Secondly, lymph nodes with positive uptake on PET were considered 
      malignant, only when nodes had neither calcification nor higher attenuation than 
      vessel pool on CT. RESULTS: One hundred and sixteen LSCCs and 234 LACs were 
      evaluated. With CT for anatomical localization, the sensitivity, specificity, 
      accuracy, positive predictive value (PPV) and negative predictive value (NPV) of 
      PET were 78.6%, 45.5%, 53.4%, 31.4% and 87.0% in LSCC group, and 61.8%, 66.3%, 
      65.0%, 42.9% and 80.9% in LAC group. PET showed higher specificity and accuracy 
      in LAC group compared with LSCC group (p=0.001 and p=0.038, respectively). 
      Considering calcification or high attenuation on CT, the sensitivity, 
      specificity, accuracy, PPV and NPV of PET/CT were 71.4%, 67.0%, 68.1%, 40.8% and 
      88.1% in LSCC group, and 54.4%, 86.1%, 76.9%, 61.7% and 82.2% in LAC group. 
      Compared with PET, PET/CT possessed higher specificity and accuracy in LSCC group 
      (p=0.000 and p=0.000, respectively), and higher specificity, accuracy and PPV in 
      LAC group (p=0.000, p=0.000 and p=0.022, respectively). CONCLUSIONS: (18)F-FDG 
      PET displays limited efficacy in assessing mediastinal lymph node metastasis with 
      the short-axis diameter <15mm in LSCC and LAC groups and higher false-positivity 
      in LSCC group. The specificity and accuracy in LSCC and LAC groups are enhanced 
      by interpreting attenuation characteristic on CT.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Lu, Peiou
AU  - Lu P
AD  - Department of PET/CT, The Affiliated Tumor Hospital of Harbin Medical University, 
      150 Haping Road, Nangang District, Harbin 150081, Heilongjiang Province, China.
FAU - Sun, Yajuan
AU  - Sun Y
AD  - Department of Radiological Diagnosis, The Affiliated Tumor Hospital of Harbin 
      Medical University, 150 Haping Road, Nangang District, Harbin, Heilongjiang 
      Province, China.
FAU - Sun, Yanqin
AU  - Sun Y
AD  - Department of PET/CT, The Affiliated Tumor Hospital of Harbin Medical University, 
      150 Haping Road, Nangang District, Harbin 150081, Heilongjiang Province, China.
FAU - Yu, Lijuan
AU  - Yu L
AD  - Department of PET/CT, The Affiliated Tumor Hospital of Harbin Medical University, 
      150 Haping Road, Nangang District, Harbin 150081, Heilongjiang Province, China. 
      Electronic address: yulijuan2003@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140418
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adenocarcinoma/*diagnostic imaging/secondary
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*diagnostic imaging/secondary
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/pathology
MH  - Lymph Nodes/*diagnostic imaging/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Mediastinum
MH  - Middle Aged
MH  - Positron-Emission Tomography
MH  - *Radiopharmaceuticals
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Lung adenocarcinoma
OT  - Lung squamous-cell carcinoma
OT  - Mediastinal lymph node metastasis
OT  - Positron emission tomography/computed tomography
EDAT- 2014/05/06 06:00
MHDA- 2015/01/21 06:00
CRDT- 2014/05/06 06:00
PHST- 2013/11/03 00:00 [received]
PHST- 2014/03/26 00:00 [revised]
PHST- 2014/04/08 00:00 [accepted]
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
AID - S0169-5002(14)00171-8 [pii]
AID - 10.1016/j.lungcan.2014.04.004 [doi]
PST - ppublish
SO  - Lung Cancer. 2014 Jul;85(1):53-8. doi: 10.1016/j.lungcan.2014.04.004. Epub 2014 
      Apr 18.