PMID- 24792343
OWN - NLM
STAT- MEDLINE
DCOM- 20141231
LR  - 20221207
IS  - 1473-6551 (Electronic)
IS  - 1350-7540 (Linking)
VI  - 27
IP  - 3
DP  - 2014 Jun
TI  - Child and adult forms of human herpesvirus 6 encephalitis: looking back, looking 
      forward.
PG  - 349-55
LID - 10.1097/WCO.0000000000000085 [doi]
AB  - PURPOSE OF REVIEW: This review evaluates publications on human herpesvirus 6 
      (HHV-6) encephalitis recognizing firstly that HHV-6A and HHV-6B are separate 
      species with differing properties, and secondly the phenomenon of chromosomal 
      integration; this occurs in a minority of persons and the complete viral genome 
      of either HHV-6A or HHV-6B is present in every nucleated cell in the body. 
      Although chromosomal integration has not been associated with disease, the 
      resulting very high level of viral DNA in human tissues and blood has sometimes 
      been wrongly misinterpreted as active infection. RECENT FINDINGS: No disease has 
      been linked to HHV-6A, whereas HHV-6B may cause encephalitis. Encephalitis due to 
      primary HHV-6B infection in young children is commonly reported from Japan, but 
      very rarely elsewhere in the world, suggesting a genetic predisposition. Reports 
      of HHV-6A or HHV-6B encephalitis in immunocompetent older children/adults are 
      most likely due to chromosomal integration and not active infection. HHV-6B 
      reactivation is well established as causing limbic encephalitis after 
      haematopoietic stem cell transplantation, particularly after receipt of cord 
      blood; the outcome is poor and preventive strategies are ineffective. SUMMARY: 
      Understanding the pathophysiology of HHV-6B encephalitis remains incomplete, 
      especially regarding young children. Clinical trials of antiviral therapy are 
      warranted for treatment and prevention of HHV-6B encephalitis after 
      transplantation.
FAU - Ward, Katherine N
AU  - Ward KN
AD  - Division of Infection & Immunity, University College London, London, UK.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Neurol
JT  - Current opinion in neurology
JID - 9319162
RN  - 0 (DNA, Viral)
RN  - 0 (Immunosuppressive Agents)
RN  - Human Herpesvirus 6 encephalitis
SB  - IM
MH  - Adult
MH  - Asian People/genetics
MH  - Child
MH  - *DNA, Viral
MH  - Encephalitis, Viral/epidemiology/genetics/*immunology
MH  - Genetic Predisposition to Disease
MH  - Hematopoietic Stem Cell Transplantation/methods
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Immunocompromised Host/*immunology
MH  - Immunosuppressive Agents/therapeutic use
MH  - Roseolovirus Infections/epidemiology/genetics/*immunology
EDAT- 2014/05/06 06:00
MHDA- 2015/01/01 06:00
CRDT- 2014/05/06 06:00
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2015/01/01 06:00 [medline]
AID - 00019052-201406000-00015 [pii]
AID - 10.1097/WCO.0000000000000085 [doi]
PST - ppublish
SO  - Curr Opin Neurol. 2014 Jun;27(3):349-55. doi: 10.1097/WCO.0000000000000085.