PMID- 24792391
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20140619
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 571
DP  - 2014 Jun 13
TI  - Fucoidan attenuates the existing allodynia and hyperalgesia in a rat model of 
      neuropathic pain.
PG  - 66-71
LID - S0304-3940(14)00341-3 [pii]
LID - 10.1016/j.neulet.2014.04.030 [doi]
AB  - Fucoidan is an active constituent found in brown seaweeds, which have potential 
      neuroprotection. The current study aimed to investigate the effects of fucoidan 
      on the maintenance of neuropathic pain induced by L5 spinal nerve ligation (SNL) 
      and the underlying mechanism related to the spinal neuroimmune responses. Animals 
      were randomized into 5 groups: sham-operation with vehicle and SNL with vehicle 
      or fucoidan (15, 50, and 100mg/kg). Different doses of fucoidan or vehicle were 
      administered intrathecally once daily from postoperative day (POD) 11-20. 
      Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) was 
      measured on 1 day before operation and days 10, 20, 22, 24, 26, 28, 30 after 
      operation. Glial activation markers such as glial fibrillary acidic protein 
      (GFAP) and macrophage antigen complex-1 (mac-1), inflammatory cytokines such as 
      tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 activation, and 
      extracellular signalregulated protein kinase (ERK) activation in the lumbar 
      spinal cord were determined on day 30 after operation. The results showed that 
      fucoidan caused dose-dependently attenuation of mechanical allodynia and thermal 
      hyperalgesia. Furthermore, fucoidan could markedly inhibit neuroimmune activation 
      characterized by glial activation, production of cytokines as well as ERK 
      activation. The analgesic effect of intrathecal fucoidan in rats receiving SNL 
      might partly attribute to the inhibition of neuroimmune activation associated 
      with the maintenance of neuropathic pain.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights 
      reserved.
FAU - Hu, Chuanyin
AU  - Hu C
AD  - Department of Biology, Guangdong Medical College, Zhanjiang, Guangdong 524023, 
      People's Republic of China.
FAU - Zhang, Guoping
AU  - Zhang G
AD  - Department of Biology, Guangdong Medical College, Zhanjiang, Guangdong 524023, 
      People's Republic of China.
FAU - Zhao, Yun-Tao
AU  - Zhao YT
AD  - Modern Biochemistry Center, Guangdong Ocean University, Zhanjiang, Guangdong 
      524088, People's Republic of China. Electronic address: yuntaozhao@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140502
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Analgesics)
RN  - 0 (Cytokines)
RN  - 0 (Polysaccharides)
RN  - 9072-19-9 (fucoidan)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Analgesics/*therapeutic use
MH  - Animals
MH  - Cytokines/metabolism
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Hot Temperature
MH  - Hyperalgesia/metabolism/physiopathology/*prevention & control
MH  - Male
MH  - Neuralgia/metabolism/physiopathology/*prevention & control
MH  - Neuroglia/drug effects/metabolism
MH  - Pain Threshold
MH  - Phosphorylation
MH  - Physical Stimulation
MH  - Polysaccharides/*therapeutic use
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/drug effects/metabolism
MH  - Spinal Nerves/injuries
MH  - Touch
OTO - NOTNLM
OT  - Fucoidan
OT  - Neuroimmune activation
OT  - Neuropathic pain
EDAT- 2014/05/06 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/05/06 06:00
PHST- 2014/02/05 00:00 [received]
PHST- 2014/04/15 00:00 [revised]
PHST- 2014/04/24 00:00 [accepted]
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0304-3940(14)00341-3 [pii]
AID - 10.1016/j.neulet.2014.04.030 [doi]
PST - ppublish
SO  - Neurosci Lett. 2014 Jun 13;571:66-71. doi: 10.1016/j.neulet.2014.04.030. Epub 
      2014 May 2.