PMID- 24792393
OWN - NLM
STAT- MEDLINE
DCOM- 20141223
LR  - 20140610
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 572
DP  - 2014 Jun 20
TI  - Spicatoside A enhances memory consolidation through the brain-derived 
      neurotrophic factor in mice.
PG  - 58-62
LID - S0304-3940(14)00345-0 [pii]
LID - 10.1016/j.neulet.2014.04.034 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays a pivotal role in memory 
      consolidation. Previously, we found that the increased mature BDNF (mBDNF) levels 
      in the hippocampal region at a specific time window after the acquisition trial 
      are required for memory consolidation. In the present study, we investigated 
      whether spicatoside A enhances memory consolidation, and whether its effects on 
      memory consolidation are related to hippocampal mBDNF levels. Spicatoside A (2.5, 
      5, 10 or 20mg/kg) enhanced memory consolidation in a dose-dependent manner, and 
      enhanced memory consolidation was also observed when spicatoside A was 
      administered 1h after the acquisition trial. Concurrently, when spicatoside A was 
      administered immediately or 1h after the acquisition trial, hippocampal mBDNF 
      levels were similar or significantly increased at 9h after the acquisition trial 
      compared to levels at 6h. These results suggest that increased mBDNF levels in 
      the hippocampal region at 9h after the acquisition trial might play a pivotal 
      role in memory consolidation and that spicatoside A might enhance memory 
      consolidation by increasing hippocampal mBDNF levels.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Kwon, Guyoung
AU  - Kwon G
AD  - Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 
      130-701, Republic of Korea; Kyung Hee East-West Pharmaceutical Research 
      Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of 
      Korea.
FAU - Lee, Hyung Eun
AU  - Lee HE
AD  - Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 
      130-701, Republic of Korea; Kyung Hee East-West Pharmaceutical Research 
      Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of 
      Korea.
FAU - Lee, Dong Hwa
AU  - Lee DH
AD  - Department of Food and Nutrition, Andong National University, Andong 760-749, 
      Republic of Korea.
FAU - Woo, Hyun
AU  - Woo H
AD  - Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 
      130-701, Republic of Korea; Kyung Hee East-West Pharmaceutical Research 
      Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of 
      Korea.
FAU - Park, Se Jin
AU  - Park SJ
AD  - Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 
      130-701, Republic of Korea; Kyung Hee East-West Pharmaceutical Research 
      Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of 
      Korea.
FAU - Gao, Qingtao
AU  - Gao Q
AD  - Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 
      130-701, Republic of Korea; Kyung Hee East-West Pharmaceutical Research 
      Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of 
      Korea.
FAU - Ahn, Young Je
AU  - Ahn YJ
AD  - Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 
      130-701, Republic of Korea; Kyung Hee East-West Pharmaceutical Research 
      Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of 
      Korea.
FAU - Son, Kun Ho
AU  - Son KH
AD  - Department of Food and Nutrition, Andong National University, Andong 760-749, 
      Republic of Korea. Electronic address: sonkh@andong.ac.kr.
FAU - Ryu, Jong Hoon
AU  - Ryu JH
AD  - Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 
      130-701, Republic of Korea; Department of Oriental Pharmaceutical Science, 
      College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea; 
      Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung 
      Hee University, Seoul 130-701, Republic of Korea. Electronic address: 
      jhryu63@khu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140502
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (5-(1-(glucopyranosyloxymethyl)ethenyl)-2-methyl-2-cyclohexen-1-one)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nootropic Agents)
RN  - 0 (Saponins)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Hippocampus/metabolism
MH  - Male
MH  - Memory/*drug effects
MH  - Mice, Inbred ICR
MH  - Nootropic Agents/*pharmacology
MH  - Saponins/*pharmacology
MH  - Time Factors
OTO - NOTNLM
OT  - BDNF
OT  - Hippocampus
OT  - Memory consolidation
OT  - Spicatoside A
EDAT- 2014/05/06 06:00
MHDA- 2014/12/24 06:00
CRDT- 2014/05/06 06:00
PHST- 2014/01/23 00:00 [received]
PHST- 2014/04/15 00:00 [revised]
PHST- 2014/04/23 00:00 [accepted]
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2014/12/24 06:00 [medline]
AID - S0304-3940(14)00345-0 [pii]
AID - 10.1016/j.neulet.2014.04.034 [doi]
PST - ppublish
SO  - Neurosci Lett. 2014 Jun 20;572:58-62. doi: 10.1016/j.neulet.2014.04.034. Epub 
      2014 May 2.