PMID- 24793433
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20161125
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 278
IP  - 3
DP  - 2014 Aug 1
TI  - Dioxin-induced retardation of development through a reduction in the expression 
      of pituitary hormones and possible involvement of an aryl hydrocarbon receptor in 
      this defect: a comparative study using two strains of mice with different 
      sensitivities to dioxin.
PG  - 220-9
LID - S0041-008X(14)00162-8 [pii]
LID - 10.1016/j.taap.2014.04.022 [doi]
AB  - We have previously revealed that treating pregnant rats with 
      2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) reduces the expression of 
      gonadotropins and growth hormone (GH) in the fetal and neonatal pituitary. A 
      change in gonadotropin expression impairs the testicular expression of 
      steroidogenic proteins in perinatal pups, and imprint defects in sexual behavior 
      after reaching maturity. In this study, we examined whether TCDD also affects the 
      expression of gonadotropin and GH in mice using C57BL/6J and DBA/2J strains which 
      express the aryl hydrocarbon receptor (Ahr) exhibiting a different affinity for 
      TCDD. When pregnant C57BL/6J mice at gestational day (GD) 12 were given oral TCDD 
      (0.2-20 mug/kg), all doses significantly attenuated the pituitary expression of 
      gonadotropin mRNAs in fetuses at GD18. On the other hand, in DBA/2J mice, a much 
      higher dose of TCDD (20 mug/kg) was needed to produce a significant attenuation. 
      Such reduction in the C57BL/6J strain continued until at least postnatal day 
      (PND) 4. In agreement with this, TCDD reduced the testicular expression of 
      steroidogenic proteins in C57BL/6J neonates at PND2 and 4, although the same did 
      not occur in the fetal testis and ovary. Furthermore, TCDD reduced the perinatal 
      expression of GH, litter size and the body weight of newborn pups only in the 
      C57BL/6J strain. These results suggest that 1) also in mice, maternal exposure to 
      TCDD attenuates gonadotropin-regulated steroidogenesis and GH expression leading 
      to the impairment of pup development and sexual immaturity; and 2) Ahr activation 
      during the late fetal and early postnatal stages is required for these defects.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Takeda, Tomoki
AU  - Takeda T
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, 
      Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Taura, Junki
AU  - Taura J
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, 
      Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Hattori, Yukiko
AU  - Hattori Y
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, 
      Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Ishii, Yuji
AU  - Ishii Y
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, 
      Higashi-ku, Fukuoka 812-8582, Japan.
FAU - Yamada, Hideyuki
AU  - Yamada H
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, 
      Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: 
      hyamada@phar.kyushu-u.ac.jp.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140502
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Ahr protein, mouse)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pituitary Hormones, Anterior)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 0 (Teratogens)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Basic Helix-Loop-Helix Transcription Factors/*agonists/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Resistance
MH  - Environmental Pollutants/administration & dosage/*toxicity
MH  - Female
MH  - Fetal Development/drug effects
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Pituitary Gland/*drug effects/embryology/metabolism
MH  - Pituitary Hormones, Anterior/genetics/*metabolism
MH  - Polychlorinated Dibenzodioxins/administration & dosage/*toxicity
MH  - Pregnancy
MH  - Receptors, Aryl Hydrocarbon/*agonists/metabolism
MH  - Sexual Development/drug effects
MH  - Specific Pathogen-Free Organisms
MH  - Teratogens/*toxicity
MH  - Testis/drug effects/metabolism
OTO - NOTNLM
OT  - 2,3,7.8-Tetrachlorodibenzo-p-dioxin (TCDD)
OT  - Aryl hydrocarbon receptor
OT  - Gonadotropin
OT  - Growth hormone
OT  - Steroidogenesis
EDAT- 2014/05/06 06:00
MHDA- 2014/09/03 06:00
CRDT- 2014/05/06 06:00
PHST- 2014/02/12 00:00 [received]
PHST- 2014/04/19 00:00 [revised]
PHST- 2014/04/21 00:00 [accepted]
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - S0041-008X(14)00162-8 [pii]
AID - 10.1016/j.taap.2014.04.022 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2014 Aug 1;278(3):220-9. doi: 10.1016/j.taap.2014.04.022. 
      Epub 2014 May 2.