PMID- 24793468
OWN - NLM
STAT- MEDLINE
DCOM- 20150126
LR  - 20240109
IS  - 1872-6968 (Electronic)
IS  - 0303-8467 (Linking)
VI  - 121
DP  - 2014 Jun
TI  - Association of HLA-DR/DQ polymorphisms with Guillain-Barre syndrome in Tunisian 
      patients.
PG  - 19-22
LID - S0303-8467(14)00103-6 [pii]
LID - 10.1016/j.clineuro.2014.03.014 [doi]
AB  - Human leukocyte antigen (HLA) alleles have been implicated in many autoimmune 
      diseases. The aim of this study is to assess whether HLA-DR/DQ alleles confer 
      susceptibility to Guillain-Barre syndrome (GBS) in a Tunisian population. 
      METHODS: The HLA-DR/DQ genotyping was performed using polymerase chain reaction 
      sequence-specific primers (PCR-SSP) in 38 patients with GBS and 100 healthy 
      Tunisian control subjects. RESULTS: GBS in Tunisian patients was found to be 
      associated with the following alleles with these relative patient versus control 
      frequencies (pc denotes Bonferroni corrected probability values): DRB1*13 (23.68% 
      vs. 9.0%; pc=0.01), followed by DRB1*14 (22.36% vs.5.5%; pc<10(-3)). Two 
      haplotypes, DRB1*14/DQB1*05 and DRB1*13/DQB1*03, were found to be associated with 
      susceptibility to GBS. However DRB1*07/DQB1*02 and DRB1*03/DQB1*02 haplotypes 
      were more frequently observed in controls than in patients (11.5% vs.7.9%; 
      pc=0.007 and 23% vs. 5.26%; pc<10(-3) respectively). These haplotypes seem to 
      confer protection against the disease. CONCLUSION: Our data demonstrated a new 
      GBS predisposition associated with HLA-DRB1*14 and DRB1*13. Theses alleles could 
      be predisposing genetic factors for GBS in the Tunisian population.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Fekih-Mrissa, Najiba
AU  - Fekih-Mrissa N
AD  - Hopital Militaire Principal d'Instruction de Tunis, Service d'Hematologie, 
      Laboratoire de Biologie Moleculaire, 1008 Montfleury, Tunis, Tunisie; Academie 
      Militaire Fondouk Jedid, 8012 Nabeul, Tunisie. Electronic address: 
      fnajiba@yahoo.fr.
FAU - Mrad, Meriem
AU  - Mrad M
AD  - Hopital Militaire Principal d'Instruction de Tunis, Service d'Hematologie, 
      Laboratoire de Biologie Moleculaire, 1008 Montfleury, Tunis, Tunisie; Universite 
      de Tunis El Manar, Faculte des Sciences de Tunis, 2092, El Manar, Tunisie.
FAU - Riahi, Anis
AU  - Riahi A
AD  - Hopital Militaire Principal d'Instruction de Tunis, Service de Neurologie, 1008 
      Montfleury, Tunis, Tunisie; Universite de Tunis El Manar, Faculte de Medecine de 
      Tunis, 1007 Tunis, Tunisie.
FAU - Sayeh, Aicha
AU  - Sayeh A
AD  - Hopital Militaire Principal d'Instruction de Tunis, Service d'Hematologie, 
      Laboratoire de Biologie Moleculaire, 1008 Montfleury, Tunis, Tunisie; Universite 
      de Tunis El Manar, Faculte des Sciences de Tunis, 2092, El Manar, Tunisie.
FAU - Zaouali, Jamel
AU  - Zaouali J
AD  - Hopital Militaire Principal d'Instruction de Tunis, Service de Neurologie, 1008 
      Montfleury, Tunis, Tunisie; Universite de Tunis El Manar, Faculte de Medecine de 
      Tunis, 1007 Tunis, Tunisie.
FAU - Gritli, Nasreddine
AU  - Gritli N
AD  - Hopital Militaire Principal d'Instruction de Tunis, Service d'Hematologie, 
      Laboratoire de Biologie Moleculaire, 1008 Montfleury, Tunis, Tunisie; Universite 
      de Monastir, Faculte de Pharmacie, 5000 Monastir, Tunisie.
FAU - Mrissa, Ridha
AU  - Mrissa R
AD  - Hopital Militaire Principal d'Instruction de Tunis, Service de Neurologie, 1008 
      Montfleury, Tunis, Tunisie; Universite de Tunis El Manar, Faculte de Medecine de 
      Tunis, 1007 Tunis, Tunisie.
LA  - eng
PT  - Journal Article
DEP - 20140319
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Guillain-Barre Syndrome/diagnosis/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Tunisia
MH  - Young Adult
OTO - NOTNLM
OT  - Guillain-Barre syndrome (GBS)
OT  - HLA
OT  - Neuroimmunology
OT  - Neuropathy
EDAT- 2014/05/06 06:00
MHDA- 2015/01/27 06:00
CRDT- 2014/05/06 06:00
PHST- 2013/06/16 00:00 [received]
PHST- 2014/01/20 00:00 [revised]
PHST- 2014/03/10 00:00 [accepted]
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
AID - S0303-8467(14)00103-6 [pii]
AID - 10.1016/j.clineuro.2014.03.014 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2014 Jun;121:19-22. doi: 10.1016/j.clineuro.2014.03.014. 
      Epub 2014 Mar 19.