PMID- 24793519
OWN - NLM
STAT- MEDLINE
DCOM- 20140722
LR  - 20181202
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 105
DP  - 2014 Jul
TI  - Expression patterns of metallothionein, cytochrome P450 1A and vitellogenin genes 
      in western mosquitofish (Gambusia affinis) in response to heavy metals.
PG  - 97-102
LID - S0147-6513(14)00152-3 [pii]
LID - 10.1016/j.ecoenv.2014.04.012 [doi]
AB  - The aim of this study was to evaluate the effects of three metals (Zn, Cd and Pb) 
      on hepatic metallothionein (MT), cytochrome P450 1A (CYP1A) and vitellogenin 
      (Vtg) mRNA expression in the liver of adult female mosquitofish (Gambusia 
      affinis) after 1, 3 or 8d. Both concentration-response and time-course effects of 
      hepatic MT, CYP1A and Vtg at the transcription level were determined by 
      quantitative real-time PCR. The results from this study showed that Zn, Cd and Pb 
      could significantly induced MT, CYP1A and Vtg mRNA expression levels in 
      mosquitofish. In general, this study demonstrated that heavy metals modulate MT, 
      CYP1A and Vtg mRNA expression levels in a metal-, concentration- or 
      time-dependent manner.
CI  - Copyright (c) 2014. Published by Elsevier Inc.
FAU - Huang, Guo-Yong
AU  - Huang GY
AD  - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. Electronic 
      address: huang_gyh@sina.com.
FAU - Ying, Guang-Guo
AU  - Ying GG
AD  - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. Electronic 
      address: guangguo.ying@gmail.com.
FAU - Liang, Yan-Qiu
AU  - Liang YQ
AD  - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
FAU - Liu, Shuang-Shuang
AU  - Liu SS
AD  - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
FAU - Liu, You-Sheng
AU  - Liu YS
AD  - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140507
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Metals, Heavy)
RN  - 0 (Vitellogenins)
RN  - 0 (Water Pollutants, Chemical)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - 9038-94-2 (Metallothionein)
SB  - IM
MH  - Animals
MH  - Cyprinodontiformes/*genetics
MH  - Cytochrome P-450 Enzyme System/genetics
MH  - Female
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/*drug effects
MH  - Liver/drug effects
MH  - Male
MH  - Metallothionein/genetics
MH  - Metals, Heavy/*toxicity
MH  - Vitellogenins/genetics
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - Cytochrome P450 1A
OT  - Heavy metals
OT  - Metallothionein
OT  - Mosquitofish
OT  - Vitellogenin
EDAT- 2014/05/06 06:00
MHDA- 2014/07/23 06:00
CRDT- 2014/05/06 06:00
PHST- 2013/11/01 00:00 [received]
PHST- 2014/04/03 00:00 [revised]
PHST- 2014/04/09 00:00 [accepted]
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2014/07/23 06:00 [medline]
AID - S0147-6513(14)00152-3 [pii]
AID - 10.1016/j.ecoenv.2014.04.012 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2014 Jul;105:97-102. doi: 10.1016/j.ecoenv.2014.04.012. 
      Epub 2014 May 7.