PMID- 24793759
OWN - NLM
STAT- MEDLINE
DCOM- 20150110
LR  - 20220408
IS  - 1862-1783 (Electronic)
IS  - 1673-1581 (Print)
IS  - 1673-1581 (Linking)
VI  - 15
IP  - 5
DP  - 2014 May
TI  - Epigenetic regulation by polycomb group complexes: focus on roles of CBX 
      proteins.
PG  - 412-28
LID - 10.1631/jzus.B1400077 [doi]
AB  - Polycomb group (PcG) complexes are epigenetic regulatory complexes that conduct 
      transcriptional repression of target genes via modifying the chromatin. The two 
      best characterized forms of PcG complexes, polycomb repressive complexes 1 and 2 
      (PRC1 and PRC2), are required for maintaining the stemness of embryonic stem 
      cells and many types of adult stem cells. The spectra of target genes for PRCs 
      are dynamically changing with cell differentiation, which is essential for proper 
      decisions on cell fate during developmental processes. Chromobox (CBX) family 
      proteins are canonical components in PRC1, responsible for targeting PRC1 to the 
      chromatin. Recent studies highlight the function specifications among CBX family 
      members in undifferentiated and differentiated stem cells, which reveal the 
      interplay between compositional diversity and functional specificity of PRC1. In 
      this review, we summarize the current knowledge about targeting and functional 
      mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins 
      under a number of physiological and pathological conditions.
FAU - Ma, Rong-gang
AU  - Ma RG
AD  - School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
FAU - Zhang, Yang
AU  - Zhang Y
FAU - Sun, Ting-ting
AU  - Sun TT
FAU - Cheng, Bo
AU  - Cheng B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
RN  - 0 (Chromatin)
RN  - 0 (Polycomb-Group Proteins)
SB  - IM
MH  - Animals
MH  - Chromatin/*genetics
MH  - Chromatin Assembly and Disassembly/*genetics
MH  - Epigenesis, Genetic/*genetics
MH  - Gene Expression Regulation/*genetics
MH  - Genes, Homeobox/*genetics
MH  - Humans
MH  - Polycomb-Group Proteins/*genetics
MH  - Transcription, Genetic/*genetics
PMC - PMC4076598
OTO - NOTNLM
OT  - Cancer
OT  - Chromobox (CBX) protein
OT  - Epigenetic regulation
OT  - Polycomb
OT  - Polycomb repressive complex 1 (PRC1)
COIS- Compliance with ethics guidelines: Rong-gang MA, Yang ZHANG, Ting-ting SUN, and 
      Bo CHENG declare that they have no conflict of interest. This article does not 
      contain any studies with human or animal subjects performed by any of the 
      authors.
EDAT- 2014/05/06 06:00
MHDA- 2015/01/13 06:00
PMCR- 2014/05/01
CRDT- 2014/05/06 06:00
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - 10.1631/jzus.B1400077 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2014 May;15(5):412-28. doi: 10.1631/jzus.B1400077.