PMID- 24794141
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20150708
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 100
IP  - 17
DP  - 2014 Sep
TI  - The single-ventricle patient population: a current and future concern a 
      population-based study in the North of England.
PG  - 1348-53
LID - 10.1136/heartjnl-2013-305336 [doi]
AB  - OBJECTIVE: To estimate the size and characteristics of the UK population with 
      single-ventricle physiology, and predict future population growth. METHODS: The 
      surviving population with single-ventricle physiology in Northern England 
      (resident population 2.9 million) was identified from our clinical database and 
      the Northern Congenital Abnormality Survey (NorCAS). Conditions included double 
      inlet ventricle, tricuspid atresia, mitral atresia, hypoplastic left heart 
      syndrome and other unbalanced defects. Fetal diagnoses, terminations of pregnancy 
      and surgical interventions were reviewed. Childhood and adult prevalence of 
      single-ventricle physiology were calculated. Current and future National 
      population figures were estimated using expected mortality derived from 
      literature. RESULTS: 80 children and 48 adults with single-ventricle physiology 
      were identified in the NorCAS region. The most frequent underlying condition in 
      childhood was hypoplastic left heart, and among adults was double inlet 
      ventricle. All children over 5 years of age had completed a Fontan repair (89%) 
      or had a Glenn anastomosis. Seven adults had not undergone a Glenn shunt or 
      Fontan procedure. Of those patients over 30 years of age (n=12), 50% were New 
      York Heart Association (NYHA) functional class 3, compared to 3% of those under 
      30 years (p=0.001). Regional childhood and adult prevalence of single-ventricle 
      physiology was 16 and 2 per 100 000, respectively. CONCLUSIONS: The current UK 
      single-ventricle population is composed of around 1040 adults and 1700 children. 
      Adult numbers will increase by over 60% in the next decade with the proportion in 
      NHYA functional class 3 set to double.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://group.bmj.com/group/rights-licensing/permissions.
FAU - Coats, Louise
AU  - Coats L
AD  - Department of Congenital Cardiology, Freeman Hospital, Newcastle Upon Tyne, UK 
      Newcastle University, Newcastle Upon Tyne, UK.
FAU - O'Connor, Sally
AU  - O'Connor S
AD  - Newcastle University, Newcastle Upon Tyne, UK.
FAU - Wren, Christopher
AU  - Wren C
AD  - Department of Congenital Cardiology, Freeman Hospital, Newcastle Upon Tyne, UK.
FAU - O'Sullivan, John
AU  - O'Sullivan J
AD  - Department of Congenital Cardiology, Freeman Hospital, Newcastle Upon Tyne, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140502
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
CIN - Heart. 2014 Sep;100(17):1315-6. PMID: 25099650
MH  - Abortion, Induced
MH  - Adolescent
MH  - Adult
MH  - Cardiac Surgical Procedures
MH  - Child
MH  - Child, Preschool
MH  - England/epidemiology
MH  - Female
MH  - Health Services Needs and Demand
MH  - Heart Defects, Congenital/diagnosis/*epidemiology/mortality/surgery
MH  - Heart Ventricles/*abnormalities/surgery
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Needs Assessment
MH  - Pregnancy
MH  - Prenatal Diagnosis
MH  - Prevalence
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - CONGENITAL HEART DISEASE
EDAT- 2014/05/06 06:00
MHDA- 2014/09/30 06:00
CRDT- 2014/05/06 06:00
PHST- 2014/05/06 06:00 [entrez]
PHST- 2014/05/06 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - heartjnl-2013-305336 [pii]
AID - 10.1136/heartjnl-2013-305336 [doi]
PST - ppublish
SO  - Heart. 2014 Sep;100(17):1348-53. doi: 10.1136/heartjnl-2013-305336. Epub 2014 May 
      2.