PMID- 24795168 OWN - NLM STAT- MEDLINE DCOM- 20140718 LR - 20161125 IS - 1879-1913 (Electronic) IS - 0002-9149 (Linking) VI - 113 IP - 12 DP - 2014 Jun 15 TI - Comparison of left ventricular function following first ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention in men versus women. PG - 1941-6 LID - S0002-9149(14)00875-3 [pii] LID - 10.1016/j.amjcard.2014.03.032 [doi] AB - Previous data reported worse outcomes in female patients after acute ST elevation myocardial infarction (STEMI), related at least in part to less aggressive and nonparallel treatment. We investigated the presence of gender differences in left ventricular (LV) systolic and diastolic function in patients presenting with first STEMI, treated with primary percutaneous coronary intervention (PCI). Study population included 187 consecutive patients (81% men) presenting with STEMI and treated by primary PCI and guideline-based medications. Their mean age was 58 +/- 10 years. All patients underwent a comprehensive echocardiographic evaluation within 3 days of admission. Female patients were older (62 +/- 11 vs 59 +/- 10 years, p = 0.006), with more co-morbidities and longer symptom duration (490 +/- 436 vs 365 +/- 437 minutes, p = 0.013). Echocardiography demonstrated that female patients had significantly lower LV systolic function (47 +/- 8% vs 45 +/- 8%, p = 0.03), lower septal and lateral e' velocities, higher average E/e' ratio (all p <0.001), elevated systolic pulmonary artery pressure (p = 0.03), and worse diastolic dysfunction (p = 0.007). No significant changes were present in left atrial volumes. In a logistic multivariate analysis model, female gender emerged as an independent predictor of septal e' <8 cm/s (odds ratio 10.11, 95% confidence interval 1.23 to 82.32, p = 0.002) and E/average e' ratio >15 (odds ratio 6.47, 95% confidence interval 1.63 to 25.61, p = 0.008). In conclusion, female patients undergoing primary PCI for first STEMI demonstrated worse systolic and diastolic LV function, despite receiving similar treatment as male patients. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Shacham, Yacov AU - Shacham Y AD - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: kobyshacham@gmail.com. FAU - Topilsky, Yan AU - Topilsky Y AD - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. FAU - Leshem-Rubinow, Eran AU - Leshem-Rubinow E AD - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. FAU - Laufer-Perl, Michal AU - Laufer-Perl M AD - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. FAU - Keren, Gad AU - Keren G AD - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. FAU - Roth, Arie AU - Roth A AD - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. FAU - Steinvil, Arie AU - Steinvil A AD - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. FAU - Arbel, Yaron AU - Arbel Y AD - Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20140401 PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 SB - IM MH - Age Factors MH - Aged MH - Angioplasty, Balloon, Coronary/methods/mortality MH - Confidence Intervals MH - Echocardiography/methods MH - Electrocardiography/methods MH - Female MH - Humans MH - Logistic Models MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Myocardial Infarction/diagnosis/*mortality/*therapy MH - Prognosis MH - Retrospective Studies MH - Risk Assessment MH - Severity of Illness Index MH - Sex Factors MH - Survival Analysis MH - Treatment Outcome MH - Ventricular Dysfunction, Left/*diagnostic imaging/*mortality/physiopathology EDAT- 2014/05/06 06:00 MHDA- 2014/07/19 06:00 CRDT- 2014/05/06 06:00 PHST- 2014/01/17 00:00 [received] PHST- 2014/03/15 00:00 [revised] PHST- 2014/03/15 00:00 [accepted] PHST- 2014/05/06 06:00 [entrez] PHST- 2014/05/06 06:00 [pubmed] PHST- 2014/07/19 06:00 [medline] AID - S0002-9149(14)00875-3 [pii] AID - 10.1016/j.amjcard.2014.03.032 [doi] PST - ppublish SO - Am J Cardiol. 2014 Jun 15;113(12):1941-6. doi: 10.1016/j.amjcard.2014.03.032. Epub 2014 Apr 1.