PMID- 24796833
OWN - NLM
STAT- MEDLINE
DCOM- 20140630
LR  - 20140506
IS  - 1460-9584 (Electronic)
IS  - 1268-7731 (Linking)
VI  - 20
IP  - 2
DP  - 2014 Jun
TI  - Clinical and oncological outcomes after surgical excision of pigmented 
      villonodular synovitis at the foot and ankle.
PG  - 130-4
LID - S1268-7731(14)00027-7 [pii]
LID - 10.1016/j.fas.2014.01.007 [doi]
AB  - BACKGROUND: Pigmented villonodular synovitis (PVNS) is a rare benign neoplastic 
      disease of the synovium of joints and tendon sheaths, which may be locally 
      aggressive. It can be broadly classified into localised disease or more diffuse 
      forms, with the latter more prone to recurrence after surgical excision. We 
      describe our experience in the management of foot and ankle PVNS, focusing on the 
      diffuse type. METHODS: Patients with PVNS were identified from a histology 
      database from 2000 to 2010 at the University Hospitals of Leicester. The primary 
      aim was to determine oncological outcomes and evaluate clinical outcomes with the 
      Toronto Extremity Salvage Score (TESS) and the American Academy of Foot and Ankle 
      Surgeons (AOFAS) scores. RESULTS: 30 patients, 16 males and 14 females with a 
      mean age of 37+/-15 years, who underwent surgery, were identified. There were 22 
      nodular PVNS and 8 diffuse PVNS. The diffuse PVNS was more likely to be in the 
      hindfoot (75%, 6/8), of which 50% (3/6) had osteoarthritis at presentation. The 
      localised PVNS was mostly located in the forefoot (91%, 20/22). None of the 
      localised PVNS had a recurrence. The surgical recurrence rate in this series was 
      similar to the pooled recurrence rate from the literature [12.5% (1/8) compared 
      to 12.2% (6/49)]. The mean TESS and AOFAS scores were 86 and 78, respectively. 
      CONCLUSIONS: Diffuse PVNS is more likely to occur in the hindfoot and nodular 
      PVNS is more common in the forefoot. Aggressive synovectomy alone is an effective 
      treatment for diffuse PVNS, with good oncological and clinical outcomes.
CI  - Copyright (c) 2014 European Foot and Ankle Society. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Korim, M T
AU  - Korim MT
AD  - Leicester Orthopaedics, University Hospitals of Leicester, Leicester General 
      Hospital, Gwendolen Road, Leicester, UK. Electronic address: 
      mtkorim@doctors.org.uk.
FAU - Clarke, D R
AU  - Clarke DR
AD  - Leicester Orthopaedics, University Hospitals of Leicester, Leicester General 
      Hospital, Gwendolen Road, Leicester, UK.
FAU - Allen, P E
AU  - Allen PE
AD  - Leicester Orthopaedics, University Hospitals of Leicester, Leicester General 
      Hospital, Gwendolen Road, Leicester, UK.
FAU - Richards, C J
AU  - Richards CJ
AD  - East Midlands Sarcoma Service, UK; Histopathology, University Hospitals of 
      Leicester, Leicester Royal Infirmary, Infirmary Square, Leicester, UK.
FAU - Ashford, R U
AU  - Ashford RU
AD  - Leicester Orthopaedics, University Hospitals of Leicester, Leicester General 
      Hospital, Gwendolen Road, Leicester, UK; East Midlands Sarcoma Service, UK; 
      Academic Orthopaedics, Trauma & Sports Medicine, University of Nottingham, Queens 
      Medical Centre, Nottingham, UK.
LA  - eng
PT  - Journal Article
DEP - 20140215
PL  - France
TA  - Foot Ankle Surg
JT  - Foot and ankle surgery : official journal of the European Society of Foot and 
      Ankle Surgeons
JID - 9609647
SB  - IM
MH  - Adult
MH  - Ankle Joint/pathology/*surgery
MH  - Databases, Factual
MH  - Female
MH  - Foot Joints/pathology/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis/*complications
MH  - Synovitis, Pigmented Villonodular/complications/*surgery
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Diffuse PVNS
OT  - Foot and ankle
OT  - Outcome scores
OT  - Pigmented villonodular synovitis
OT  - Recurrence
OT  - Surgical excision
EDAT- 2014/05/07 06:00
MHDA- 2014/07/01 06:00
CRDT- 2014/05/07 06:00
PHST- 2013/10/18 00:00 [received]
PHST- 2014/01/18 00:00 [revised]
PHST- 2014/01/27 00:00 [accepted]
PHST- 2014/05/07 06:00 [entrez]
PHST- 2014/05/07 06:00 [pubmed]
PHST- 2014/07/01 06:00 [medline]
AID - S1268-7731(14)00027-7 [pii]
AID - 10.1016/j.fas.2014.01.007 [doi]
PST - ppublish
SO  - Foot Ankle Surg. 2014 Jun;20(2):130-4. doi: 10.1016/j.fas.2014.01.007. Epub 2014 
      Feb 15.