PMID- 24797301
OWN - NLM
STAT- MEDLINE
DCOM- 20150419
LR  - 20140709
IS  - 1029-2470 (Electronic)
IS  - 1029-2470 (Linking)
VI  - 48
IP  - 8
DP  - 2014 Aug
TI  - (-)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction 
      and autophagy in diabetic Goto-Kakizaki rats.
PG  - 898-906
LID - 10.3109/10715762.2014.920955 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a risk factor for heart disease. However, the 
      mechanisms of T2DM involvement in cardiac complications are still unclear. In the 
      present study, we investigated mitochondria-related mechanisms underlying the 
      pathogenesis of myocardial disorders in diabetic Goto-Kakizaki (GK) rats. We 
      found that remarkable myocardial mitochondrial deficiency and dysfunction as well 
      as oxidative stress occurred in the heart of GK rats. In addition, our results 
      suggested that the loss of mitochondria was in response to elevated autophagy and 
      upstream FoxO factors in diabetic myocardium. More importantly, 
      (-)-epigallocatechin-3-gallate (EGCG), a polyphenol derived from green tea, 
      successfully improved mitochondrial function and autophagy in the heart of GK 
      rats. Our findings revealed that diabetes-associated myocardial mitochondrial 
      deficiency and dysfunction was associated with enhanced autophagy in myocardium, 
      and EGCG might be a potential agent in preventing and treating myocardial 
      disorders involved in diabetes.
FAU - Liu, J
AU  - Liu J
AD  - Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical 
      Information Engineering of the Ministry of Education, School of Life Science and 
      Technology and Frontier Institute of Life Science, FIST, Xi'an Jiaotong 
      University , Xi'an , P. R. China.
FAU - Tang, Y
AU  - Tang Y
FAU - Feng, Z
AU  - Feng Z
FAU - Liu, J
AU  - Liu J
FAU - Liu, J
AU  - Liu J
FAU - Long, J
AU  - Long J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140604
PL  - England
TA  - Free Radic Res
JT  - Free radical research
JID - 9423872
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
SB  - IM
MH  - Animals
MH  - Autophagy/drug effects
MH  - Catechin/*analogs & derivatives/pharmacology
MH  - Diabetes Mellitus, Experimental/drug therapy/metabolism/pathology
MH  - Disease Models, Animal
MH  - Male
MH  - Mitochondria, Heart/*drug effects/*metabolism
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - EGCG
OT  - autophagy
OT  - diabetes
OT  - mitochondrial dysfunction
OT  - myocardium
EDAT- 2014/05/07 06:00
MHDA- 2015/04/22 06:00
CRDT- 2014/05/07 06:00
PHST- 2014/05/07 06:00 [entrez]
PHST- 2014/05/07 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
AID - 10.3109/10715762.2014.920955 [doi]
PST - ppublish
SO  - Free Radic Res. 2014 Aug;48(8):898-906. doi: 10.3109/10715762.2014.920955. Epub 
      2014 Jun 4.