PMID- 24797652
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20181202
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 20
IP  - 5
DP  - 2014 Oct
TI  - Adverse events in hospitalized paediatric patients: a systematic review and a 
      meta-regression analysis.
PG  - 551-8
LID - 10.1111/jep.12141 [doi]
AB  - RATIONALE, AIMS AND OBJECTIVES: To gain insight into the incidence of paediatric 
      adverse events (AEs); to assess if there are significant differences among study 
      results and to what extent methodological issues can explain them. METHODS: From 
      November 2012 to January 2013, systematic literature searches were conducted on 
      PubMed, Scopus and the Cochrane Library. We selected studies from 1970 onwards 
      that evaluated the incidence of AEs in hospitalized paediatric patients and 
      included a minimum of 1000 patient records with the same definition of AE. 
      Studies that reported only specific AEs or only a specific ward were not 
      considered. Data were extracted on the method of data collection, study design, 
      type of hospital, and the timing of the AE in relation to its discovery and the 
      index admission (time frame). AE incidence and preventability were considered. 
      RESULTS: The pooled incidence of AEs was 2.0% (95% CI: 1.3-3.0%). Five 
      methodological differences among studies were taken into account. Only the time 
      frame of detected events had a statistically significant effect on the incidence 
      of AEs (P<0.0001). The pooled incidence of preventable AEs was 46.2% (95% CI: 
      35.3-57.5%) with a high variability among studies. CONCLUSIONS: Our meta-analysis 
      confirms that AEs are a major public health issue. Although studies use the same 
      definition of AE, the reported incidence of AEs and preventable AEs varied 
      considerably. To direct prevention efforts properly, studies methodologically 
      more homogeneous and more detailed about the standard of health care provided and 
      the health system organization are needed.
CI  - (c) 2014 John Wiley & Sons, Ltd.
FAU - Berchialla, Paola
AU  - Berchialla P
AD  - Department of Clinical and Biological Sciences, University of Torino, Torino, 
      Italy.
FAU - Scaioli, Giacomo
AU  - Scaioli G
FAU - Passi, Stefano
AU  - Passi S
FAU - Gianino, Maria M
AU  - Gianino MM
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20140505
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - Child
MH  - Data Collection/methods
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Medical Errors/classification/prevention & control/*statistics & numerical data
MH  - Patient Safety/*statistics & numerical data
MH  - Retrospective Studies
MH  - Time Factors
OTO - NOTNLM
OT  - clinical safety
OT  - systematic reviews
EDAT- 2014/05/07 06:00
MHDA- 2015/05/27 06:00
CRDT- 2014/05/07 06:00
PHST- 2014/03/28 00:00 [accepted]
PHST- 2014/05/07 06:00 [entrez]
PHST- 2014/05/07 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - 10.1111/jep.12141 [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2014 Oct;20(5):551-8. doi: 10.1111/jep.12141. Epub 2014 May 5.