PMID- 24797673
OWN - NLM
STAT- MEDLINE
DCOM- 20150922
LR  - 20180330
IS  - 1439-0396 (Electronic)
IS  - 0931-2439 (Linking)
VI  - 99
IP  - 1
DP  - 2015 Feb
TI  - In ovo carbohydrate supplementation modulates growth and immunity-related genes 
      in broiler chickens.
PG  - 163-173
LID - 10.1111/jpn.12193 [doi]
AB  - A study was undertaken to investigate the role of in ovo administrated 
      carbohydrates on the expression pattern of growth and immune-related genes. In 
      ovo injections (n = 400) were carried out on the 14th day of incubation into the 
      yolk sac/amnion of the broiler chicken embryos. Expression of growth-related 
      genes: chicken growth hormone (cGH), insulin-like growth factor-I & II (IGF-I & 
      II) and mucin were studied in hepatic and jejunum tissues of late-term embryo and 
      early post-hatch chicks. Expression of candidate immune genes: Interleukin-2, 6, 
      10 and 12 (IL-2, IL-6, IL-10 and IL-12), Tumour necrosis factor-alpha (TNF-alpha) and 
      Interferon gamma (IFN-gamma) were studied in peripheral blood monocyte cells of in 
      ovo-injected and control birds following antigenic stimulation with sheep RBC 
      (SRBC) or mitogen concanavalin A (Con-A). Glucose injection significantly 
      increased the expression of IGF-II gene during embryonic period and both cGH and 
      IGF-II in early post-hatch period, while ribose-injected chicks had higher 
      expression of IGF-II gene during embryonic stage. Enhanced mucin gene expression 
      was also observed in fructose-injected chicks during embryonic age. 
      Glucose-injected chicks had higher expression of IL-6 or IL-10, while those 
      injected with fructose or ribose had higher expression of IL-2, IL-12 and IFN 
      gamma. It is concluded that in ovo supplementation of carbohydrates might help in 
      improving the growth of late-term embryos and chicks. In ovo glucose could 
      modulate humoral-related immunity, while fructose or ribose might help in 
      improving the cellular immunity in broiler chickens.
CI  - Journal of Animal Physiology and Animal Nutrition (c) 2014 Blackwell Verlag GmbH.
FAU - Bhanja, S K
AU  - Bhanja SK
AD  - Central Avian Research Institute, Izatnagar, UP, India.
FAU - Goel, A
AU  - Goel A
AD  - Central Avian Research Institute, Izatnagar, UP, India.
FAU - Pandey, N
AU  - Pandey N
AD  - Central Avian Research Institute, Izatnagar, UP, India.
FAU - Mehra, M
AU  - Mehra M
AD  - Central Avian Research Institute, Izatnagar, UP, India.
FAU - Majumdar, S
AU  - Majumdar S
AD  - Central Avian Research Institute, Izatnagar, UP, India.
FAU - Mandal, A B
AU  - Mandal AB
AD  - Central Avian Research Institute, Izatnagar, UP, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140505
PL  - Germany
TA  - J Anim Physiol Anim Nutr (Berl)
JT  - Journal of animal physiology and animal nutrition
JID - 101126979
RN  - 0 (Carbohydrates)
SB  - IM
MH  - Animals
MH  - Carbohydrates/administration & dosage/*pharmacology
MH  - Chick Embryo
MH  - Chickens/*growth & development/*immunology
MH  - Gene Expression Regulation/*drug effects/immunology
MH  - Ovum
OTO - NOTNLM
OT  - broiler chickens
OT  - carbohydrates
OT  - gene expression
OT  - growth and immunity
OT  - in ovo injection
EDAT- 2014/05/07 06:00
MHDA- 2015/09/24 06:00
CRDT- 2014/05/07 06:00
PHST- 2013/07/12 00:00 [received]
PHST- 2014/03/27 00:00 [accepted]
PHST- 2014/05/07 06:00 [entrez]
PHST- 2014/05/07 06:00 [pubmed]
PHST- 2015/09/24 06:00 [medline]
AID - 10.1111/jpn.12193 [doi]
PST - ppublish
SO  - J Anim Physiol Anim Nutr (Berl). 2015 Feb;99(1):163-173. doi: 10.1111/jpn.12193. 
      Epub 2014 May 5.