PMID- 24798210
OWN - NLM
STAT- MEDLINE
DCOM- 20150129
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 5
DP  - 2014
TI  - Medication monitoring in a nurse-led respiratory outpatient clinic: pragmatic 
      randomised trial of the West Wales Adverse Drug Reaction Profile.
PG  - e96682
LID - 10.1371/journal.pone.0096682 [doi]
LID - e96682
AB  - OBJECTIVE: To assess the clinical effect of medication monitoring using the West 
      Wales Adverse Drug Reaction (ADR) Profile for Respiratory Medicine. DESIGN: 
      Single-site parallel-arm pragmatic trial using stratified randomisation. SETTING: 
      Nurse-led respiratory outpatient clinic in general hospital in South Wales. 
      PARTICIPANTS: 54 patients with chronic respiratory disease receiving 
      bronchodilators, corticosteroids or leukotriene receptor antagonists. 
      INTERVENTION: Following initial observation of usual nursing care, we allocated 
      participants at random to receive at follow up: either the West Wales ADR Profile 
      for Respiratory Medicine in addition to usual care ('intervention arm' with 26 
      participants); or usual care alone ('control arm' with 28 participants). MAIN 
      OUTCOME MEASURES: Problems reported and actions taken. RESULTS: We followed up 
      all randomised participants, and analysed data in accordance with treatment 
      allocated. The increase in numbers of problems per participant identified at 
      follow up was significantly higher in the intervention arm, where the median 
      increase was 20.5 [inter-quartile range (IQR) 13-26], while that in the control 
      arm was -1 [-3 to +2] [Mann-Whitney U test: z = 6.28, p<0.001]. The increase in 
      numbers of actions per participant taken at follow up was also significantly 
      higher in the intervention arm, where the median increase was 2.5 [1]-[4] while 
      that in the control arm was 0 [-1.75 to +1] [Mann-Whitney U test: z = 4.40, 
      p<0.001]. CONCLUSION: When added to usual nursing care, the West Wales ADR 
      Profile identified more problems and prompted more nursing actions. Our ADR 
      Profile warrants further investigation as a strategy to optimise medication 
      management. TRIAL REGISTRATION: Controlled-trials.com ISRCTN10386209.
FAU - Gabe, Marie E
AU  - Gabe ME
AD  - College of Human and Health Sciences, Swansea University, Swansea, United 
      Kingdom.
FAU - Murphy, Fiona
AU  - Murphy F
AD  - College of Human and Health Sciences, Swansea University, Swansea, United 
      Kingdom.
FAU - Davies, Gwyneth A
AU  - Davies GA
AD  - ABM University Health Board, Wales, United Kingdom; College of Medicine, Swansea 
      University, Swansea, United Kingdom.
FAU - Russell, Ian T
AU  - Russell IT
AD  - West Wales Organisation for Rigorous Trials in Health, and College of Medicine, 
      Swansea University, Swansea, United Kingdom.
FAU - Jordan, Susan
AU  - Jordan S
AD  - College of Human and Health Sciences, Swansea University, Swansea, United 
      Kingdom.
LA  - eng
SI  - ISRCTN/ISRCTN10386209
PT  - Journal Article
PT  - Pragmatic Clinical Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140505
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Leukotriene Antagonists)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - *Adverse Drug Reaction Reporting Systems
MH  - Aged
MH  - Ambulatory Care Facilities
MH  - Bronchodilator Agents/therapeutic use
MH  - *Drug Monitoring
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Leukotriene Antagonists/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Nurses
MH  - Nursing/*methods
MH  - Outpatients
MH  - Patient Safety
MH  - Respiration Disorders/*drug therapy/*therapy
MH  - Wales
PMC - PMC4010491
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/05/07 06:00
MHDA- 2015/01/30 06:00
PMCR- 2014/05/05
CRDT- 2014/05/07 06:00
PHST- 2013/06/10 00:00 [received]
PHST- 2014/04/04 00:00 [accepted]
PHST- 2014/05/07 06:00 [entrez]
PHST- 2014/05/07 06:00 [pubmed]
PHST- 2015/01/30 06:00 [medline]
PHST- 2014/05/05 00:00 [pmc-release]
AID - PONE-D-13-24859 [pii]
AID - 10.1371/journal.pone.0096682 [doi]
PST - epublish
SO  - PLoS One. 2014 May 5;9(5):e96682. doi: 10.1371/journal.pone.0096682. eCollection 
      2014.