PMID- 24798939
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 75
IP  - 8
DP  - 2014 Aug
TI  - Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of 
      herpes simplex virus infections and diseases across global populations: 
      implication for the development of an universal CD8+ T-cell epitope-based 
      vaccine.
PG  - 715-29
LID - S0198-8859(14)00127-X [pii]
LID - 10.1016/j.humimm.2014.04.016 [doi]
AB  - A significant portion of the world's population is infected with herpes simplex 
      virus type 1 and/or type 2 (HSV-1 and/or HSV-2), that cause a wide range of 
      diseases including genital herpes, oro-facial herpes, and the potentially 
      blinding ocular herpes. While the global prevalence and distribution of HSV-1 and 
      HSV-2 infections cannot be exactly established, the general trends indicate that: 
      (i) HSV-1 infections are much more prevalent globally than HSV-2; (ii) over a 
      half billion people worldwide are infected with HSV-2; (iii) the sub-Saharan 
      African populations account for a disproportionate burden of genital herpes 
      infections and diseases; (iv) the dramatic differences in the prevalence of 
      herpes infections between regions of the world appear to be associated with 
      differences in the frequencies of human leukocyte antigen (HLA) alleles. The 
      present report: (i) analyzes the prevalence of HSV-1 and HSV-2 infections across 
      various regions of the world; (ii) analyzes potential associations of common 
      HLA-A, HLA-B and HLA-C alleles with the prevalence of HSV-1 and HSV-2 infections 
      in the Caucasoid, Oriental, Hispanic and Black major populations; and (iii) 
      discusses how our recently developed HLA-A, HLA-B, and HLA-C transgenic/H-2 class 
      I null mice will help validate HLA/herpes prevalence associations. Overall, high 
      prevalence of herpes infection and disease appears to be associated with high 
      frequency of HLA-A( *)24, HLA-B( *)27, HLA-B( *)53 and HLA-B( *)58 alleles. In 
      contrast, low prevalence of herpes infection and disease appears to be associated 
      with high frequency of HLA-B( *)44 allele. The finding will aid in developing a 
      T-cell epitope-based universal herpes vaccine and immunotherapy.
CI  - Copyright (c) 2014 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Samandary, Sarah
AU  - Samandary S
AD  - Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, 
      School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
FAU - Kridane-Miledi, Hedia
AU  - Kridane-Miledi H
AD  - UNITE INSERM 1016, Institut Cochin, Hopital Saint-Vincent-de-Paul, 82, Avenue 
      Denfert-Rochereau, 75674 Paris Cedex 14, France.
FAU - Sandoval, Jacqueline S
AU  - Sandoval JS
AD  - Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, 
      School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
FAU - Choudhury, Zareen
AU  - Choudhury Z
AD  - Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, 
      School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
FAU - Langa-Vives, Francina
AU  - Langa-Vives F
AD  - Plate-Forme Technologique, Centre d'Ingenierie Genetique Murine, Departement de 
      Biologie du Developpement, Institut Pasteur, 75015 Paris, France.
FAU - Spencer, Doran
AU  - Spencer D
AD  - Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, 
      School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
FAU - Chentoufi, Aziz A
AU  - Chentoufi AA
AD  - Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, 
      School of Medicine, University of California Irvine, Irvine, CA 92697, USA.
FAU - Lemonnier, Francois A
AU  - Lemonnier FA
AD  - UNITE INSERM 1016, Institut Cochin, Hopital Saint-Vincent-de-Paul, 82, Avenue 
      Denfert-Rochereau, 75674 Paris Cedex 14, France.
FAU - BenMohamed, Lbachir
AU  - BenMohamed L
AD  - Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, 
      School of Medicine, University of California Irvine, Irvine, CA 92697, USA; 
      Department of Molecular Biology & Biochemistry, University of California Irvine, 
      Irvine, CA 92697, USA; Institute for Immunology, University of California Irvine, 
      Irvine, CA 92697, USA. Electronic address: Lbenmoha@uci.edu.
LA  - eng
GR  - EY14900/EY/NEI NIH HHS/United States
GR  - EY019896/EY/NEI NIH HHS/United States
GR  - R01 EY019896/EY/NEI NIH HHS/United States
GR  - R01 EY014900/EY/NEI NIH HHS/United States
GR  - R01 EY024618/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140504
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Herpes Simplex Virus Vaccines)
SB  - IM
MH  - Africa/epidemiology
MH  - Alleles
MH  - Americas/epidemiology
MH  - Animals
MH  - Asia/epidemiology
MH  - Epitopes, T-Lymphocyte/genetics/immunology
MH  - Europe/epidemiology
MH  - Gene Expression
MH  - Gene Frequency
MH  - HLA-A Antigens/*genetics/immunology
MH  - HLA-B Antigens/*genetics/immunology
MH  - HLA-C Antigens/*genetics/immunology
MH  - Herpes Genitalis/epidemiology/*immunology/prevention & control/virology
MH  - Herpes Labialis/epidemiology/*immunology/prevention & control/virology
MH  - Herpes Simplex Virus Vaccines/immunology
MH  - Herpesvirus 1, Human/*immunology
MH  - Herpesvirus 2, Human/*immunology
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - Prevalence
MH  - T-Lymphocytes/immunology/virology
PMC - PMC4119854
MID - NIHMS589295
OTO - NOTNLM
OT  - Alleles
OT  - CD8+ T-Cell
OT  - Epitope
OT  - Frequency
OT  - HLA-A
OT  - HLA-B
OT  - HLA-C
OT  - Herpes Simplex Virus
OT  - Prevalence
OT  - Vaccine
COIS- Conflict of Interest: The authors have declared that no conflict of interest 
      exists
EDAT- 2014/05/07 06:00
MHDA- 2015/03/31 06:00
PMCR- 2015/08/01
CRDT- 2014/05/07 06:00
PHST- 2013/12/28 00:00 [received]
PHST- 2014/04/15 00:00 [revised]
PHST- 2014/04/15 00:00 [accepted]
PHST- 2014/05/07 06:00 [entrez]
PHST- 2014/05/07 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - S0198-8859(14)00127-X [pii]
AID - 10.1016/j.humimm.2014.04.016 [doi]
PST - ppublish
SO  - Hum Immunol. 2014 Aug;75(8):715-29. doi: 10.1016/j.humimm.2014.04.016. Epub 2014 
      May 4.