PMID- 24799969
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140506
LR  - 20211021
IS  - 1934-7820 (Print)
IS  - 1934-7987 (Electronic)
IS  - 1934-7820 (Linking)
VI  - 7
IP  - 2
DP  - 2014 Mar
TI  - Absence of anaplastic lymphoma kinase translocations in signet ring cell 
      carcinomas of the upper gastrointestinal tract.
PG  - 39-41
AB  - BACKGROUND: Anaplastic lymphoma kinase (ALK) fusion oncogenes are present in 
      multiple cancer types. The inversion of echinoderm microtubule-associated 
      protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) genes on chromosome 2 
      is present in a subset of patients with non-small-cell lung cancer (NSCLC). 
      ALK-rearranged lung cancers demonstrate a significantly higher incidence of 
      signet ring cell histology than do ALK-negative tumors. Based on the histologic 
      similarities of ALK-rearranged NSCLC and signet ring cell carcinomas (SRCCs) of 
      the gastrointestinal tract, we hypothesized that SRCC of the upper 
      gastrointestinal (GI) tract may also harbor ALK translocations. METHODS: 
      Thirty-five formalin-fixed, paraffin-embedded (FFPE) diagnostic tissue specimens 
      of SRCC or poorly differentiated adenocarcinoma with greater than 10% signet ring 
      cell features originating from the upper GI tract were obtained and confirmed by 
      a board-certified, GI pathologist. SRCC specimens were analyzed by fluorescence 
      in situ hybridization (FISH) analysis, with an ALK (2p23) break-apart probe. 
      RESULTS: The FISH analysis revealed no evidence of ALK translocation. All 35 
      (100%) SRCC specimens showed intact ALK FISH signals. CONCLUSIONS: These data 
      indicate that, despite histologic similarities between SRCC of the upper GI tract 
      and ALK-positive NSCLC, ALK translocations are unlikely to be a significant 
      contributor to the molecular etiology of SRCC. Further genomic investigations are 
      ongoing.
FAU - Miller, Jill
AU  - Miller J
AD  - Department of Pathology.
FAU - Peng, Zhihua
AU  - Peng Z
AD  - Department of Pathology.
FAU - Wilcox, Rebecca
AU  - Wilcox R
AD  - Department of Pathology.
FAU - Evans, Mark
AU  - Evans M
AD  - Department of Pathology.
FAU - Ades, Steven
AU  - Ades S
AD  - Division of Hematology Oncology The University of Vermont Cancer Center 
      Burlington, VT.
FAU - Verschraegen, Claire
AU  - Verschraegen C
AD  - Division of Hematology Oncology The University of Vermont Cancer Center 
      Burlington, VT.
LA  - eng
GR  - T32 ES007122/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Gastrointest Cancer Res
JT  - Gastrointestinal cancer research : GCR
JID - 101300691
PMC - PMC4007674
EDAT- 2014/05/07 06:00
MHDA- 2014/05/07 06:01
PMCR- 2014/03/01
CRDT- 2014/05/07 06:00
PHST- 2013/06/03 00:00 [received]
PHST- 2013/11/13 00:00 [accepted]
PHST- 2014/05/07 06:00 [entrez]
PHST- 2014/05/07 06:00 [pubmed]
PHST- 2014/05/07 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - 0194 [pii]
PST - ppublish
SO  - Gastrointest Cancer Res. 2014 Mar;7(2):39-41.