PMID- 24800544
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20190221
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 28
IP  - 4
DP  - 2014 Feb
TI  - [The expression and clinical significance of OPN and C-met in laryngeal 
      carcinoma].
PG  - 256-8
AB  - OBJECTIVE: To investigate the protein expression of OPN and C-met and their 
      relationship with tumorigenesis, invasion and cancer metastasis in laryngeal 
      squamous cell carcinoma (LSCC). METHOD: The expression of OPN and C-met were 
      detected immunohistochemical method(Elivision plus)in 52 laryngeal squamous 
      carcinoma and 30 adjacent tissues, to analyse the relationship between their 
      expression levels and clinical stages, differentiation grades and the metastasis 
      of pelvic lymph nodes. RESULT: The expression of OPN and C-met in laryngeal 
      squamous carcinoma and adjacent tissues were 71.2%, 6.7% and 63.5 %,16.7%, 
      respectively. The positive rate of OPN and C-met with LSCC in stage I-II is 48.1% 
      and 55.6%, and that in 25 cases of stage III-IV is 96.0% and 80.0%, with 
      significant difference among them. The positive rate of OPN is significantly 
      lower in the cases without-metastasis of lymph node (53.6%) than that in the ones 
      with-metastasis of lymph node (91.7%). The positive rate of C-met in the 
      metastasis cases is 83.3%, which is much higher than that in the cases 
      without-metastasis (46.4%). The positive rate of OPN and C-met in squamous cell 
      carcinoma with high, medium-grade differentiation is 65.7% and 54.3%, and that in 
      17 cases of in squamous cell carcinoma with low-grade differentiation is 82.4%. 
      The OPN and C-met positive rate have negative correlations with differentiation 
      grades. CONCLUSION: Expression of OPN and C-met were higher with advance of 
      clinical stages, and it has relation to the metastasis of lymph, but it's 
      difficult to say that there is regular relation between expression of OPN and 
      C-met and differentiation grades. Expression of OPN and C-met have positive 
      correlation in LSCC, and abnormal expression of OPN and C-met have some effect on 
      tumor invasion and metastasis in LSCC patients.
FAU - Zhang, Yue
AU  - Zhang Y
FAU - Zhao, Junjun
AU  - Zhao J
FAU - Zhang, Qingfeng
AU  - Zhang Q
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (SPP1 protein, human)
RN  - 106441-73-0 (Osteopontin)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Osteopontin/*metabolism
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-met/*metabolism
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2014/05/08 06:00
MHDA- 2014/12/23 06:00
CRDT- 2014/05/08 06:00
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Feb;28(4):256-8.