PMID- 24800930
OWN - NLM
STAT- MEDLINE
DCOM- 20150401
LR  - 20220409
IS  - 1435-4373 (Electronic)
IS  - 0934-9723 (Linking)
VI  - 33
IP  - 9
DP  - 2014 Sep
TI  - The association between chronic osteomyelitis and increased risk of diabetes 
      mellitus: a population-based cohort study.
PG  - 1647-52
LID - 10.1007/s10096-014-2126-7 [doi]
AB  - Chronic inflammation is a well-known risk factor for type 2 diabetes mellitus 
      (T2DM). The influence of chronic osteomyelitis (COM), an inflammatory disease, on 
      the risk of developing T2DM remains unknown. This study investigated the risk of 
      developing T2DM among COM patients. Using a retrospective cohort study, we 
      identified 20,641 patients with COM and 82,564 age- and sex-matched controls for 
      comparison from the Taiwan National Health Insurance Database (NHIRD) from 1997 
      to 2010. We followed up the COM cohort and the comparison cohort to compare the 
      incidences of diabetes (ICD-9-CM code 250) until the end of 2010 or until the 
      patients were censored because of death or withdrawal from the insurance program. 
      The diabetes risk was analyzed using the Cox proportional hazards regression 
      model. The incidence of T2DM was 1.6-fold higher in the group of COM patients 
      than in the comparison group (29.1 vs. 18.2 per 10,000 person-years). The COM 
      patients exhibited a higher diabetes risk [adjusted hazard ratio (aHR) = 1.64, 95 
      % confidence interval (CI) = 1.44-1.87] after controlling for the baseline and 
      comorbidities. Younger and higher income patients exhibited a higher 
      COM-to-reference incidence rate ratio (IRR) for T2DM compared with that of their 
      counterparts. We also observed an increased risk of T2DM in COM patients with 
      comorbidities (aHR = 1.70, 95 % CI = 1.47-1.96) compared with that of their 
      non-COM counterparts. This is the first study to report the association between 
      COM and an increased risk of developing T2DM, particularly among younger and 
      higher income patients.
FAU - Lin, S-Y
AU  - Lin SY
AD  - Graduate Institute of Clinical Medical Science and School of Medicine, College of 
      Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung, 404, Taiwan.
FAU - Lin, C-L
AU  - Lin CL
FAU - Tseng, C-H
AU  - Tseng CH
FAU - Wang, I-K
AU  - Wang IK
FAU - Wang, S-M
AU  - Wang SM
FAU - Huang, C-C
AU  - Huang CC
FAU - Chang, Y-J
AU  - Chang YJ
FAU - Kao, C-H
AU  - Kao CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140507
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official 
      publication of the European Society of Clinical Microbiology
JID - 8804297
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Osteomyelitis/*complications
MH  - Risk Assessment
MH  - Socioeconomic Factors
MH  - Taiwan/epidemiology
MH  - Young Adult
EDAT- 2014/05/08 06:00
MHDA- 2015/04/02 06:00
CRDT- 2014/05/08 06:00
PHST- 2014/02/05 00:00 [received]
PHST- 2014/04/11 00:00 [accepted]
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2015/04/02 06:00 [medline]
AID - 10.1007/s10096-014-2126-7 [doi]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1647-52. doi: 
      10.1007/s10096-014-2126-7. Epub 2014 May 7.