PMID- 24801510
OWN - NLM
STAT- MEDLINE
DCOM- 20140729
LR  - 20140819
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 6
DP  - 2014 May 6
TI  - Topographic localization of macular retinal ganglion cell loss associated with 
      localized peripapillary retinal nerve fiber layer defect.
PG  - 3501-8
LID - 10.1167/iovs.14-13925 [doi]
AB  - PURPOSE: To investigate the topographic relationship between ganglion cell-inner 
      plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) 
      defects in open-angle glaucoma patients with localized RNFL defects, using 
      spectral-domain optical coherence tomography (SD-OCT). METHODS: We analyzed 140 
      eyes of 140 patients showing a localized RNFL defect in one hemifield, the 
      angular width of which was limited to one clock-hour sector. The RNFL and macular 
      GCIPL scans were obtained using SD-OCT. The clock-hour location and width of 
      pRNFL defects on the RNFL deviation map were determined, and their topographic 
      association with corresponding GCIPL defects on the GCIPL deviation map was 
      assessed. RESULTS: A "GCIPL deviation frequency map" demonstrating GCIPL defects 
      corresponding to six different clock-hour locations of pRNFL defects was 
      obtained, and it revealed the following specifics: (1) pRNFL defect at 12, 11, 
      and 10 o'clock corresponded to GCIPL defect in the superior macula, as those at 
      8, 7, and 6 o'clock did to those in the inferior macula; (2) the overall GCIPL 
      defect had an arcuate shape that appeared as a continuation of the pRNFL defect; 
      (3) the temporal macular region was the frequently damaged site in either 
      hemifield, and was larger in the inferior hemifield than in the superior 
      hemifield. Additionally, an interindividual variability of GCIPL defect was noted 
      for patients with the same clock-hour location of pRNFL defect. CONCLUSIONS: The 
      GCIPL deviation frequency map demonstrating the topographic relationship between 
      pRNFL and GCIPL defects was generated using SD-OCT. Our results indicated the 
      topographic location of retinal ganglion cell death associated with clock-hour 
      location of pRNFL loss in vivo.
CI  - Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Kim, Ko Eun
AU  - Kim KE
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, Korea.
FAU - Park, Ki Ho
AU  - Park KH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, Korea.
FAU - Yoo, Beong Wook
AU  - Yoo BW
AD  - Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National 
      University, Seoul, Korea.
FAU - Jeoung, Jin Wook
AU  - Jeoung JW
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, Korea.
FAU - Kim, Dong Myung
AU  - Kim DM
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea Department of Ophthalmology, Seoul National University Hospital, 
      Seoul, Korea.
FAU - Kim, Hee Chan
AU  - Kim HC
AD  - Department of Biomedical Engineering, College of Medicine and Institute of 
      Medical and Biological Engineering, Medical Research Center, Seoul National 
      University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140506
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Female
MH  - Follow-Up Studies
MH  - Glaucoma, Open-Angle/complications/*pathology/physiopathology
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - ROC Curve
MH  - Retinal Diseases/etiology/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
OTO - NOTNLM
OT  - ganglion cell-inner plexiform layer defect
OT  - peripapillary retinal nerve fiber layer defect
OT  - spectral-domain optical coherence tomography
OT  - topographic relationship
EDAT- 2014/05/08 06:00
MHDA- 2014/07/30 06:00
CRDT- 2014/05/08 06:00
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - iovs.14-13925 [pii]
AID - 10.1167/iovs.14-13925 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 May 6;55(6):3501-8. doi: 10.1167/iovs.14-13925.