PMID- 24801583
OWN - NLM
STAT- MEDLINE
DCOM- 20150212
LR  - 20170917
IS  - 1520-6017 (Electronic)
IS  - 0022-3549 (Linking)
VI  - 103
IP  - 7
DP  - 2014 Jul
TI  - The role of payload hydrophobicity in nanotherapeutic pharmacokinetics.
PG  - 2147-2156
LID - S0022-3549(15)30509-8 [pii]
LID - 10.1002/jps.23996 [doi]
AB  - Although drug delivery with nanovectors is regarded as one of the 
      paradigm-shifting advances in modern medicine, the compatibility and performance 
      of drug-vector formulations have not been systematically studied in terms of 
      their physicochemistry and pharmacokinetics (PKs). The drug delivery systems 
      (DDSs), currently available in clinics or trials, were analyzed based on 
      hydrophobicity and anatomical therapeutic chemical (ATC) classification of drug 
      payloads. Four major types of DDSs differentiated based on DDS structure and drug 
      hydrophobicity, where payload hydrophobicity decreased: micelles, serum albumin, 
      liposome membrane, and liposome interior. A strong relationship between the 
      increase in half-life in DDS formulation and drug hydrophobicity was found with 
      up to 200-fold greater increase for hydrophilic drugs. The analysis results 
      seemingly integrated PKs, ATC, and hydrophobicity to reinforce the development or 
      optimization of drug delivery vectors and their formulations.
CI  - (c) 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.
FAU - Norvaisas, Povilas
AU  - Norvaisas P
AD  - Houston Methodist Research Institute, Department of Nanomedicine, Houston, Texas, 
      77030.
FAU - Ziemys, Arturas
AU  - Ziemys A
AD  - Houston Methodist Research Institute, Department of Nanomedicine, Houston, Texas, 
      77030. Electronic address: aziemys@hostonmethodist.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140506
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Drug Carriers)
RN  - 0 (Liposomes)
RN  - 0 (Micelles)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Chemical Phenomena
MH  - Data Interpretation, Statistical
MH  - Databases, Pharmaceutical
MH  - Drug Carriers/*chemistry
MH  - Drug Liberation
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Liposomes
MH  - Micelles
MH  - Nanoparticles/*chemistry
MH  - Particle Size
MH  - *Pharmaceutical Preparations/administration & dosage/chemistry/metabolism
MH  - *Pharmacokinetics
MH  - Protein Binding
MH  - Serum Albumin/chemistry/metabolism
OTO - NOTNLM
OT  - albumin
OT  - formulation
OT  - formulation vehicles
OT  - lipoproteins
OT  - liposomes
OT  - log P
OT  - micelles
OT  - nanoparticles
OT  - pharmacokinetics
OT  - physicochemical
EDAT- 2014/05/08 06:00
MHDA- 2015/02/13 06:00
CRDT- 2014/05/08 06:00
PHST- 2014/03/31 00:00 [received]
PHST- 2014/03/26 00:00 [revised]
PHST- 2014/04/07 00:00 [accepted]
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2015/02/13 06:00 [medline]
AID - S0022-3549(15)30509-8 [pii]
AID - 10.1002/jps.23996 [doi]
PST - ppublish
SO  - J Pharm Sci. 2014 Jul;103(7):2147-2156. doi: 10.1002/jps.23996. Epub 2014 May 6.