PMID- 24801685
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20220330
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 59
IP  - 6
DP  - 2014 Jun
TI  - Adiponectin inhibits murine pancreatic cancer growth.
PG  - 1192-6
LID - 10.1007/s10620-014-3175-6 [doi]
AB  - BACKGROUND: Adiponectin is an adipose tissue-derived secretory hormone whose 
      plasma concentrations are lower in obese individuals. Obesity is a risk factor 
      for the development and growth of pancreatic cancer, and hypoadiponectinemia was 
      suggested to be involved in the growth of Pan02 murine pancreatic cancer cells 
      that were inoculated into the flanks of congenitally obese mice. AIM: The aim of 
      this study was to clarify the role of adiponectin in the growth of pancreatic 
      cancer cells. METHODS: We examined the effect of adiponectin on the growth of 
      Pan02 cells using recombinant adiponectin and adiponectin knockout mice. RESULTS: 
      The in vitro treatment of Pan02 cells with adiponectin inhibited cellular 
      proliferation that was accompanied by increased apoptosis and caspase-3 and 
      caspase-7 activities. Transplantation of Pan02 cells into the pancreas of 
      knockout mice resulted in a larger tumor volume with fewer terminal 
      deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) positive 
      cells compared with wild-type mice. CONCLUSIONS: The results indicate that 
      adiponectin directly suppresses the proliferation of Pan02 cells.
FAU - Kato, Motohiko
AU  - Kato M
AD  - Department of Gastroenterology and Hepatology, Osaka University Graduate School 
      of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
FAU - Watabe, Kenji
AU  - Watabe K
FAU - Tsujii, Masahiko
AU  - Tsujii M
FAU - Funahashi, Tohru
AU  - Funahashi T
FAU - Shimomura, Iichiro
AU  - Shimomura I
FAU - Takehara, Tetsuo
AU  - Takehara T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140507
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Adiponectin)
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adiponectin/*pharmacology
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Mice
MH  - Mice, Knockout
MH  - Pancreatic Neoplasms/*drug therapy
EDAT- 2014/05/08 06:00
MHDA- 2014/07/16 06:00
CRDT- 2014/05/08 06:00
PHST- 2013/12/22 00:00 [received]
PHST- 2014/04/16 00:00 [accepted]
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1007/s10620-014-3175-6 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2014 Jun;59(6):1192-6. doi: 10.1007/s10620-014-3175-6. Epub 2014 May 
      7.