PMID- 24801751 OWN - NLM STAT- MEDLINE DCOM- 20150512 LR - 20220318 IS - 1878-4216 (Electronic) IS - 0278-5846 (Linking) VI - 54 DP - 2014 Oct 3 TI - Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder. PG - 43-9 LID - S0278-5846(14)00088-8 [pii] LID - 10.1016/j.pnpbp.2014.04.010 [doi] AB - DNA methylation allows for the environmental regulation of gene expression and is believed to link environmental stressors to such mental-illness phenotypes as eating disorders. Numerous studies have shown an association between bulimia nervosa (BN) and variations in brain-derived neurotrophic factor (BDNF). BDNF has also been linked to borderline personality disorder (BPD) and to such traits as reward dependence. We examined the extent to which BDNF methylation corresponded to bulimic or normal-eater status, and also to the presence of comorbid borderline personality disorder (BPD) and childhood abuse. Our sample consisted of 64 women with BN and 32 normal-eater (NE) control women. Participants were assessed for eating-disorder symptoms, comorbid psychopathology, and childhood trauma, and then they were required to provide blood samples for methylation analyses. We observed a significant sitexgroup (BN vs. NE) interaction indicating that women with BN showed increases in methylation at specific regions of the BDNF promoter. Furthermore, examining effects of childhood abuse and BPD, we observed significant sitexgroup interactions such that groups composed of individuals with childhood abuse or BPD had particularly high levels of methylation at selected CpG sites. Our findings suggest that BN, especially when co-occurring with childhood abuse or BPD, is associated with a propensity towards elevated methylation at specific BDNF promoter region sites. These findings imply that hypermethylation of the BDNF gene may be related to eating disorder status, developmental stress exposure, and comorbid psychopathology. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Thaler, Lea AU - Thaler L AD - Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada; Psychiatry Department, McGill University, Montreal, Quebec, Canada; Research Centre, Douglas University Institute, Montreal, Quebec, Canada. FAU - Gauvin, Lise AU - Gauvin L AD - Research Centre, Centre Hospitalier de l'Universite de Montreal, Monteal, Quebec, Canada; Department of Social & Preventive Medicine, School of Public Health, Universite de Montreal, Montreal, Quebec, Canada. FAU - Joober, Ridha AU - Joober R AD - Research Centre, Douglas University Institute, Montreal, Quebec, Canada. FAU - Groleau, Patricia AU - Groleau P AD - Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada; Research Centre, Douglas University Institute, Montreal, Quebec, Canada. FAU - de Guzman, Rosherrie AU - de Guzman R AD - Research Centre, Douglas University Institute, Montreal, Quebec, Canada. FAU - Ambalavanan, Amirthagowri AU - Ambalavanan A AD - Research Centre, Douglas University Institute, Montreal, Quebec, Canada. FAU - Israel, Mimi AU - Israel M AD - Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada; Psychiatry Department, McGill University, Montreal, Quebec, Canada; Research Centre, Douglas University Institute, Montreal, Quebec, Canada. FAU - Wilson, Samantha AU - Wilson S AD - Psychology Department, Universite de Montreal, Montreal, Quebec, Canada. FAU - Steiger, Howard AU - Steiger H AD - Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada; Psychiatry Department, McGill University, Montreal, Quebec, Canada; Research Centre, Douglas University Institute, Montreal, Quebec, Canada. Electronic address: howard.steiger@douglas.mcgill.ca. LA - eng PT - Journal Article DEP - 20140505 PL - England TA - Prog Neuropsychopharmacol Biol Psychiatry JT - Progress in neuro-psychopharmacology & biological psychiatry JID - 8211617 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Borderline Personality Disorder/blood/epidemiology/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Bulimia Nervosa/blood/epidemiology/*genetics MH - Child MH - *Child Abuse MH - Comorbidity MH - CpG Islands MH - *DNA Methylation MH - Female MH - Humans MH - Promoter Regions, Genetic MH - Psychiatric Status Rating Scales OTO - NOTNLM OT - Abuse OT - BDNF OT - Borderline personality disorder OT - Bulimia nervosa OT - Epigenetics OT - Methylation EDAT- 2014/05/08 06:00 MHDA- 2015/05/13 06:00 CRDT- 2014/05/08 06:00 PHST- 2014/02/13 00:00 [received] PHST- 2014/03/24 00:00 [revised] PHST- 2014/04/23 00:00 [accepted] PHST- 2014/05/08 06:00 [entrez] PHST- 2014/05/08 06:00 [pubmed] PHST- 2015/05/13 06:00 [medline] AID - S0278-5846(14)00088-8 [pii] AID - 10.1016/j.pnpbp.2014.04.010 [doi] PST - ppublish SO - Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:43-9. doi: 10.1016/j.pnpbp.2014.04.010. Epub 2014 May 5.