PMID- 24801912
OWN - NLM
STAT- MEDLINE
DCOM- 20150916
LR  - 20211021
IS  - 1941-2703 (Electronic)
IS  - 1941-2711 (Print)
IS  - 1941-2711 (Linking)
VI  - 28
IP  - 1
DP  - 2015 Feb
TI  - Physicochemical characterization of nebulized superparamagnetic iron oxide 
      nanoparticles (SPIONs).
PG  - 43-51
LID - 10.1089/jamp.2013.1117 [doi]
AB  - BACKGROUND: Aerosol-mediated delivery of nano-based therapeutics to the lung has 
      emerged as a promising alternative for treatment and prevention of lung diseases. 
      Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted significant 
      attention for such applications due to their biocompatibility and magnetic 
      properties. However, information is lacking about the characteristics of 
      nebulized SPIONs for use as a therapeutic aerosol. To address this need, we 
      conducted a physicochemical characterization of nebulized Rienso, a SPION-based 
      formulation for intravenous treatment of anemia. METHODS: Four different 
      concentrations of SPION suspensions were nebulized with a one-jet nebulizer. 
      Particle size was measured in suspension by transmission electron microscopy 
      (TEM), photon correlation spectroscopy (PCS), and nanoparticle tracking analysis 
      (NTA), and in the aerosol by a scanning mobility particle sizer (SMPS). RESULTS: 
      The average particle size in suspension as measured by TEM, PCS, and NTA was 
      9+/-2 nm, 27+/-7 nm, and 56+/-10 nm, respectively. The particle size in suspension 
      remained the same before and after the nebulization process. However, after 
      aerosol collection in an impinger, the suspended particle size increased to 
      159+/-46 nm as measured by NTA. The aerosol particle concentration increased 
      linearly with increasing suspension concentration, and the aerodynamic diameter 
      remained relatively stable at around 75 nm as measured by SMPS. CONCLUSIONS: We 
      demonstrated that the total number and particle size in the aerosol were 
      modulated as a function of the initial concentration in the nebulizer. The data 
      obtained mark the first known independent characterization of nebulized Rienso 
      and, as such, provide critical information on the behavior of Rienso 
      nanoparticles in an aerosol. The data obtained in this study add new knowledge to 
      the existing body of literature on potential applications of SPION suspensions as 
      inhaled aerosol therapeutics.
FAU - Graczyk, Halshka
AU  - Graczyk H
AD  - 1 Institute for Work and Health, University of Lausanne and Geneva , 1066 
      Epalinges-Lausanne, Switzerland .
FAU - Bryan, Louise C
AU  - Bryan LC
FAU - Lewinski, Nastassja
AU  - Lewinski N
FAU - Suarez, Guillaume
AU  - Suarez G
FAU - Coullerez, Geraldine
AU  - Coullerez G
FAU - Bowen, Paul
AU  - Bowen P
FAU - Riediker, Michael
AU  - Riediker M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140506
PL  - United States
TA  - J Aerosol Med Pulm Drug Deliv
JT  - Journal of aerosol medicine and pulmonary drug delivery
JID - 101475057
RN  - 0 (Aerosols)
RN  - 0 (Hematinics)
RN  - 0 (Magnetite Nanoparticles)
MH  - Administration, Inhalation
MH  - Aerosols
MH  - Hematinics/*administration & dosage/chemistry
MH  - Linear Models
MH  - Magnetite Nanoparticles/*administration & dosage/chemistry
MH  - Motion
MH  - *Nebulizers and Vaporizers
MH  - Particle Size
PMC - PMC4367499
OTO - NOTNLM
OT  - Rienso
OT  - SPIONs
OT  - aerosol distribution
OT  - characterization
OT  - inhaled therapy
OT  - nebulizer
EDAT- 2014/05/08 06:00
MHDA- 2015/09/17 06:00
PMCR- 2015/02/01
CRDT- 2014/05/08 06:00
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2015/09/17 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - 10.1089/jamp.2013.1117 [pii]
AID - 10.1089/jamp.2013.1117 [doi]
PST - ppublish
SO  - J Aerosol Med Pulm Drug Deliv. 2015 Feb;28(1):43-51. doi: 10.1089/jamp.2013.1117. 
      Epub 2014 May 6.