PMID- 24802554
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20211021
IS  - 1559-064X (Electronic)
IS  - 1559-0631 (Print)
IS  - 1559-0631 (Linking)
VI  - 25
IP  - 3
DP  - 2015 May
TI  - Persistent organic pollutants (POPs) and fibroids: results from the ENDO study.
PG  - 278-85
LID - 10.1038/jes.2014.31 [doi]
AB  - To evaluate the association between persistent organic pollutants (POPs) and 
      uterine fibroids, we used previously collected data from a cohort of women aged 
      18-44 years undergoing laparoscopy or laparotomy at 14 participating hospital 
      surgical centers (n=473). POP concentrations were measured in omental fat and 
      serum. Presence of fibroids was defined on the basis of a postoperative diagnosis 
      (n=99). Odds ratios (OR) and 95% confidence interval (CI) for each POP by 
      biologic medium were estimated using unconditional logistic regression adjusted 
      for identified covariates. Concentrations were higher in omental fat than in 
      serum for all POPs. Serum p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was 
      the only POP associated with fibroids (per 1-SD increase in log-transformed 
      p,p'-DDE OR (95% CI): 1.37 (1.05-1.80)). In analyses excluding women diagnosed 
      with endometriosis, a number of polychlorinated biphenyls (PCBs) measured in 
      omental fat were associated with fibroids (PCB 99: 1.64 (1.08, 2.49); PCB 138: 
      1.64 (1.03, 2.59); PCB 146: 1.54 (1.01, 2.37); PCB 153: 1.88 (1.12, 3.13); PCB 
      196: 1.60 (1.02, 2.51); PCB 206: 1.52 (1.01, 2.29)). Although exploratory, our 
      study suggests that PCBs may be associated with fibroids in the absence of other 
      gynecologic disorders such as endometriosis, but the associations varied by 
      biologic media with more POPs emerging when quantified in fat.
FAU - Trabert, Britton
AU  - Trabert B
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National 
      Institutes of Health, Department of Health and Human Services, Bethesda, 
      Maryland, USA.
FAU - Chen, Zhen
AU  - Chen Z
AD  - Division of Intramural Population Health Research, Eunice Kennedy Shriver 
      National Institute of Child Health and Human Development, National Institutes of 
      Health, Department of Health and Human Services, Rockville, Maryland, USA.
FAU - Kannan, Kurunthachalam
AU  - Kannan K
AD  - Division of Environmental Health Sciences, Wadsworth Center, New York State 
      Department of Health and the Department of Environmental Health Sciences, 
      University at Albany, State University of New York, Albany, New York, USA.
FAU - Peterson, C Matthew
AU  - Peterson CM
AD  - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics 
      and Gynecology, University of Utah, Salt Lake City, Utah, USA.
FAU - Pollack, Anna Z
AU  - Pollack AZ
AD  - Department of Global and Community Health, College of Health and Human Services, 
      George Mason University, Fairfax, Virginia, USA.
FAU - Sun, Liping
AU  - Sun L
AD  - Division of Intramural Population Health Research, Eunice Kennedy Shriver 
      National Institute of Child Health and Human Development, National Institutes of 
      Health, Department of Health and Human Services, Rockville, Maryland, USA.
FAU - Buck Louis, Germaine M
AU  - Buck Louis GM
AD  - Division of Intramural Population Health Research, Eunice Kennedy Shriver 
      National Institute of Child Health and Human Development, National Institutes of 
      Health, Department of Health and Human Services, Rockville, Maryland, USA.
LA  - eng
GR  - Z01 HD008729-07/Intramural NIH HHS/United States
GR  - N01-DK-6-3427/DK/NIDDK NIH HHS/United States
GR  - 10001406-02/PHS HHS/United States
GR  - N01-DK-6-3428/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20140507
PL  - United States
TA  - J Expo Sci Environ Epidemiol
JT  - Journal of exposure science & environmental epidemiology
JID - 101262796
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Dichlorodiphenyl Dichloroethylene/analysis/toxicity
MH  - Environmental Monitoring
MH  - Environmental Pollutants/analysis/*toxicity
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis/*toxicity
MH  - Intra-Abdominal Fat/chemistry
MH  - Leiomyoma/*chemically induced
MH  - Logistic Models
MH  - Odds Ratio
MH  - Omentum/chemistry
MH  - Risk Factors
MH  - Uterine Neoplasms/*chemically induced
MH  - Young Adult
PMC - PMC4410838
MID - NIHMS679538
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2014/05/08 06:00
MHDA- 2016/01/20 06:00
PMCR- 2016/05/01
CRDT- 2014/05/08 06:00
PHST- 2014/01/15 00:00 [received]
PHST- 2014/03/16 00:00 [revised]
PHST- 2014/03/19 00:00 [accepted]
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - jes201431 [pii]
AID - 10.1038/jes.2014.31 [doi]
PST - ppublish
SO  - J Expo Sci Environ Epidemiol. 2015 May;25(3):278-85. doi: 10.1038/jes.2014.31. 
      Epub 2014 May 7.