PMID- 24802731
OWN - NLM
STAT- MEDLINE
DCOM- 20151231
LR  - 20170302
IS  - 2299-8306 (Electronic)
IS  - 0423-104X (Linking)
VI  - 65
IP  - 2
DP  - 2014
TI  - The effect of calpain-10 gene polymorphism on the development of type 2 diabetes 
      mellitus in a Turkish population.
PG  - 90-5
LID - 10.5603/EP.2014.0013 [doi]
AB  - INTRODUCTION: The variations in the Calpain-10 gene have been suggested to be 
      related to susceptibility to type 2 diabetes mellitus (T2DM) in different 
      populations. In this study, we investigated the relationship between single 
      nucleotide polymorphism (SNP)-19, -44 and -63 in the Calpain-10 gene and the 
      development of T2DM in a Turkish population. MATERIAL AND METHODS: A total of 211 
      subjects were recruited: 118 patients with a diagnosis of T2DM and 93 unrelated 
      healthy subjects. RESULTS: There were no significant differences in the genotype 
      and allele distribution of SNPs studied between the patients with T2DM and 
      controls (p > 0.05), whereas the frequencies of 121 haplotype and 122/121 
      haplotype combination were found to be higher in patients with T2DM than in 
      controls (p < 0.05). No association was observed between the variations in the 
      Calpain-10 gene and glycaemic control and lipid parameters (p > 0.05). The SNP-19 
      insertion/insertion was significantly related to increased body mass index (BMI) 
      in male diabetic patients (p < 0.05). CONCLUSIONS: The present study indicates 
      that 121 haplotype and 122/121 haplotype combination of SNP-19, -44 and -63 in 
      the Calpain-10 gene are associated with the development of T2DM in Turkish 
      patients.
FAU - Arslan, Emre
AU  - Arslan E
FAU - Acik, Leyla
AU  - Acik L
FAU - Gunaltili, Gulsah
AU  - Gunaltili G
FAU - Ayvaz, Goksun
AU  - Ayvaz G
FAU - Altinova, Alev E
AU  - Altinova AE
AD  - alevaltinova@yahoo.com.
FAU - Arslan, Metin
AU  - Arslan M
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Endokrynol Pol
JT  - Endokrynologia Polska
JID - 0370674
RN  - EC 3.4.22.- (Calpain)
RN  - EC 3.4.22.- (calpain 10)
SB  - IM
MH  - Adult
MH  - Calpain/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Turkey
EDAT- 2014/05/08 06:00
MHDA- 2016/01/01 06:00
CRDT- 2014/05/08 06:00
PHST- 2014/05/06 00:00 [received]
PHST- 2014/05/06 00:00 [accepted]
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2016/01/01 06:00 [medline]
AID - VM/OJS/J/38182 [pii]
AID - 10.5603/EP.2014.0013 [doi]
PST - ppublish
SO  - Endokrynol Pol. 2014;65(2):90-5. doi: 10.5603/EP.2014.0013.