PMID- 24802877
OWN - NLM
STAT- MEDLINE
DCOM- 20150116
LR  - 20240503
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 15
IP  - 5
DP  - 2014 May 5
TI  - Association of dioxin and other persistent organic pollutants (POPs) with 
      diabetes: epidemiological evidence and new mechanisms of beta cell dysfunction.
PG  - 7787-811
LID - 10.3390/ijms15057787 [doi]
AB  - The worldwide explosion of the rates of diabetes and other metabolic diseases in 
      the last few decades cannot be fully explained only by changes in the prevalence 
      of classical lifestyle-related risk factors, such as physical inactivity and poor 
      diet. For this reason, it has been recently proposed that other "nontraditional" 
      risk factors could contribute to the diabetes epidemics. In particular, an 
      increasing number of reports indicate that chronic exposure to and accumulation 
      of a low concentration of environmental pollutants (especially the so-called 
      persistent organic pollutants (POPs)) within the body might be associated with 
      diabetogenesis. In this review, the epidemiological evidence suggesting a 
      relationship between dioxin and other POPs exposure and diabetes incidence will 
      be summarized, and some recent developments on the possible underlying 
      mechanisms, with particular reference to dioxin, will be presented and discussed.
FAU - De Tata, Vincenzo
AU  - De Tata V
AD  - Department of Translational Research and New Technologies in Medicine and 
      Surgery, University of Pisa, Via Roma, 55, Scuola Medica, 56126 Pisa, Italy. 
      vincenzo.detata@med.unipi.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140505
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Dioxins)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus/*chemically induced/epidemiology/metabolism/*pathology
MH  - Dioxins/*adverse effects/toxicity
MH  - Endocrine Disruptors/*adverse effects/toxicity
MH  - Environmental Pollutants/*adverse effects/toxicity
MH  - Humans
MH  - Incidence
MH  - Insulin-Secreting Cells/drug effects/metabolism/*pathology
MH  - Risk Factors
MH  - Signal Transduction/drug effects
PMC - PMC4057704
EDAT- 2014/05/08 06:00
MHDA- 2015/01/17 06:00
PMCR- 2014/05/01
CRDT- 2014/05/08 06:00
PHST- 2014/02/19 00:00 [received]
PHST- 2014/04/16 00:00 [revised]
PHST- 2014/04/21 00:00 [accepted]
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2015/01/17 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - ijms15057787 [pii]
AID - ijms-15-07787 [pii]
AID - 10.3390/ijms15057787 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 May 5;15(5):7787-811. doi: 10.3390/ijms15057787.