PMID- 24802957 OWN - NLM STAT- MEDLINE DCOM- 20150112 LR - 20161020 IS - 1897-5631 (Electronic) IS - 0239-8508 (Linking) VI - 52 IP - 1 DP - 2014 TI - Dendritic cells in autoimmune disorders and cancer of the thyroid. PG - 18-28 LID - 10.5603/FHC.2014.0002 [doi] AB - Dendritic cells (DCs), considered as one of the crucial immune regulatory populations, are implicated in the immune pathology of various disorders. Also in the thyroid gland, DCs were shown to be involved in early and chronic phases of various types of autoimmunity - including Hashimoto's thyroiditis and Graves' disease. In thyroid malignant processes, DCs are suggested as an important element of both tumour defence and tumour immune evasion mechanisms. Recent findings emphasize a crucial role of interactions between particular DC subsets and other regulatory cell populations (e.g. FoxP3+ regulatory T cells) in thyroid pathology. Additionally, an increasing attention has been paid to the control of DC function by thyrometabolic conditions. FAU - Lewinski, Andrzej AU - Lewinski A AD - Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital, Lodz, Poland. alewin@csk.umed.lodz.pl. FAU - Sliwka, Przemyslaw Wiktor AU - Sliwka PW FAU - Stasiolek, Mariusz AU - Stasiolek M LA - eng PT - Journal Article PT - Review PL - Poland TA - Folia Histochem Cytobiol JT - Folia histochemica et cytobiologica JID - 8502651 SB - IM MH - Animals MH - Dendritic Cells/*pathology/*physiology MH - Graves Disease/*immunology/pathology MH - Humans MH - T-Lymphocytes, Regulatory/physiology MH - Thyroid Gland/cytology/immunology MH - Thyroid Neoplasms/etiology/*immunology/pathology MH - Thyroiditis, Autoimmune/*immunology/pathology EDAT- 2014/05/08 06:00 MHDA- 2015/01/13 06:00 CRDT- 2014/05/08 06:00 PHST- 2014/01/03 00:00 [received] PHST- 2014/03/10 00:00 [accepted] PHST- 2014/02/24 00:00 [revised] PHST- 2014/05/08 06:00 [entrez] PHST- 2014/05/08 06:00 [pubmed] PHST- 2015/01/13 06:00 [medline] AID - VM/OJS/J/36716 [pii] AID - 10.5603/FHC.2014.0002 [doi] PST - ppublish SO - Folia Histochem Cytobiol. 2014;52(1):18-28. doi: 10.5603/FHC.2014.0002.