PMID- 24803243
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20161125
IS  - 1558-2639 (Electronic)
IS  - 1536-1241 (Linking)
VI  - 13
IP  - 2
DP  - 2014 Jun
TI  - Direct label-free electrical immunodetection of transplant rejection protein 
      biomarker in physiological buffer using floating gate AlGaN/GaN high electron 
      mobility transistors.
PG  - 138-45
LID - 10.1109/TNB.2014.2318234 [doi]
AB  - Monokine induced by interferon gamma (MIG/CXCL9) is used as an immune biomarker 
      for early monitoring of transplant or allograft rejection. This paper 
      demonstrates a direct electrical, label-free detection method of recombinant 
      human MIG with anti-MIG IgG molecules in physiologically relevant buffer 
      environment. The sensor platform used is a biologically modified GaN-based high 
      electron mobility transistor (HEMT) device. Biomolecular recognition capability 
      was provided by using high affinity anti-MIG monoclonal antibody to form 
      molecular affinity interface receptors on short N-hydroxysuccinimide-ester 
      functionalized disulphide (DSP) self-assembled monolayers (SAMs) on the gold 
      sensing gate of the HEMT device. A floating gate configuration has been adopted 
      to eliminate the influences of external gate voltage. Preliminary test results 
      with the proposed chemically treated GaN HEMT biosensor show that MIG can be 
      detected for a wide range of concentration varying from 5 ng/mL to 500 ng/mL.
FAU - Tulip, Fahmida S
AU  - Tulip FS
FAU - Eteshola, Edward
AU  - Eteshola E
FAU - Desai, Suchita
AU  - Desai S
FAU - Mostafa, Salwa
AU  - Mostafa S
FAU - Roopa, Subramanian
AU  - Roopa S
FAU - Evans, Boyd
AU  - Evans B
FAU - Islam, Syed Kamrul
AU  - Islam SK
LA  - eng
GR  - EB004960/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140424
PL  - United States
TA  - IEEE Trans Nanobioscience
JT  - IEEE transactions on nanobioscience
JID - 101152869
RN  - 0 (Aluminum Compounds)
RN  - 0 (Biomarkers)
RN  - 0 (Buffers)
RN  - 0 (CXCL9 protein, human)
RN  - 0 (Chemokine CXCL9)
RN  - 0 (Immunoglobulin G)
RN  - 0 (aluminum gallium nitride)
RN  - 1R9CC3P9VL (gallium nitride)
RN  - CH46OC8YV4 (Gallium)
SB  - IM
MH  - Aluminum Compounds/*chemistry
MH  - Biomarkers/analysis
MH  - *Biosensing Techniques
MH  - Buffers
MH  - Chemokine CXCL9/*analysis/immunology
MH  - Electrons
MH  - Gallium/*chemistry
MH  - Humans
MH  - Immunoglobulin G/immunology
MH  - *Transistors, Electronic
EDAT- 2014/05/08 06:00
MHDA- 2015/01/16 06:00
CRDT- 2014/05/08 06:00
PHST- 2014/05/08 06:00 [entrez]
PHST- 2014/05/08 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
AID - 10.1109/TNB.2014.2318234 [doi]
PST - ppublish
SO  - IEEE Trans Nanobioscience. 2014 Jun;13(2):138-45. doi: 10.1109/TNB.2014.2318234. 
      Epub 2014 Apr 24.