PMID- 24805361
OWN - NLM
STAT- MEDLINE
DCOM- 20150123
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 5
DP  - 2014
TI  - Estrogenic regulation of histamine receptor subtype H1 expression in the 
      ventromedial nucleus of the hypothalamus in female rats.
PG  - e96232
LID - 10.1371/journal.pone.0096232 [doi]
LID - e96232
AB  - Female sexual behavior is controlled by central estrogenic action in the 
      ventromedial nucleus of the hypothalamus (VMN). This region plays a pivotal role 
      in facilitating sex-related behavior in response to estrogen stimulation via 
      neural activation by several neurotransmitters, including histamine, which 
      participates in this mechanism through its strong neural potentiating action. 
      However, the mechanism through which estrogen signaling is linked to the 
      histamine system in the VMN is unclear. This study was undertaken to investigate 
      the relationship between estrogen and histamine receptor subtype H1 (H1R), which 
      is a potent subtype among histamine receptors in the brain. We show localization 
      of H1R exclusively in the ventrolateral subregion of the female VMN (vl VMN), and 
      not in the dorsomedial subregion. In the vl VMN, abundantly expressed H1R were 
      mostly colocalized with estrogen receptor alpha. Intriguingly, H1R mRNA levels in the 
      vl VMN were significantly elevated in ovariectomized female rats treated with 
      estrogen benzoate. These data suggest that estrogen can amplify histamine 
      signaling by enhancing H1R expression in the vl VMN. This enhancement of 
      histamine signaling might be functionally important for allowing neural 
      excitation in response to estrogen stimulation of the neural circuit and may 
      serve as an accelerator of female sexual arousal.
FAU - Mori, Hiroko
AU  - Mori H
AD  - Department of Medical Education, Kyoto Prefectural University of Medicine, 
      Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, Japan.
FAU - Matsuda, Ken-Ichi
AU  - Matsuda K
AD  - Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, 
      Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, Japan.
FAU - Yamawaki, Masanaga
AU  - Yamawaki M
AD  - Department of Medical Education, Kyoto Prefectural University of Medicine, 
      Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, Japan.
FAU - Kawata, Mitsuhiro
AU  - Kawata M
AD  - Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, 
      Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140507
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Histamine H1)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Estrogens/*pharmacology
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, Histamine H1/genetics/*metabolism
MH  - Ventromedial Hypothalamic Nucleus/*drug effects/*metabolism
PMC - PMC4013143
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/05/09 06:00
MHDA- 2015/01/24 06:00
PMCR- 2014/05/07
CRDT- 2014/05/09 06:00
PHST- 2013/05/08 00:00 [received]
PHST- 2014/04/04 00:00 [accepted]
PHST- 2014/05/09 06:00 [entrez]
PHST- 2014/05/09 06:00 [pubmed]
PHST- 2015/01/24 06:00 [medline]
PHST- 2014/05/07 00:00 [pmc-release]
AID - PONE-D-13-18872 [pii]
AID - 10.1371/journal.pone.0096232 [doi]
PST - epublish
SO  - PLoS One. 2014 May 7;9(5):e96232. doi: 10.1371/journal.pone.0096232. eCollection 
      2014.